1378912-66-3

Basic information

• Product Name: (2S)-methyl 2-(((((5S,6R,8R,9R)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-9-hydroxy-1,7-dioxaspiro[4.4]nonan-8-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
• CAS NO: 1378912-66-3
• Molecular Weight: 525.452
• Mol File: 1378912-66-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S)-methyl 2-(((((5S,6R,8R,9R)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-9-hydroxy-1,7-dioxaspiro[4.4]nonan-8-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-methyl 2-(((((5S,6R,8R,9R)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-9-hydroxy-1,7-dioxaspiro[4.4]nonan-8-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate(1378912-66-3)
• EPA Substance Registry System: (2S)-methyl 2-(((((5S,6R,8R,9R)-6-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-9-hydroxy-1,7-dioxaspiro[4.4]nonan-8-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate(1378912-66-3)

Safety Data

• Hazardous Substances Data: 1378912-66-3(Hazardous Substances Data)

Upstream product

• 770-12-7 O-phenyl phosphorodichloridate 
• 664333-52-2 1-[2-O,2-C-propano-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil 
• 142629-80-9 phenyl methoxyalaninyl phosphorochloridate 
• 664333-53-3 1-(2-O,2-C-propano-β-D-arabinofuranosyl)uracil 

Relevant articles and documents

Use of 2′-spirocyclic ethers in HCV nucleoside design

Conformationally restricted 2′-spironucleosides and their prodrugs were synthesized as potential anti-HCV agents. Although the replicon activity of the new agents containing pyrimidine bases was modest, the triphosphate of a 2′-oxetane cytidine analogue demonstrated potent intrinsic biochemical activity against the NS5B polymerase, with IC50 = 8.48 μM. Activity against NS5B bearing the S282T mutation was reduced. Phosphoramidate prodrugs of a 2′-oxetane 2-amino-6-O-methyl-purine nucleoside demonstrated potent anti-HCV activity in vitro, and the corresponding triphosphate retained similar potent activity against both wild-type and S282T HCV NS5B polymerase.