137896-02-7

Basic information

• Product Name: 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE
• Synonyms: 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE;2-ACETAMIDO-6-CHLORO-9-(2’,3’,5’-TRI-O-ACETYL-B-D-RIBOFURANOSYL)PURINE;2-Acetamido-6-chloro-9-(2’,3’,5’-tri-O-acetyl--D-ribofuranosyl)purine;N-[6-Chloro-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purin-2-yl]acetaMide
• CAS NO: 137896-02-7
• Molecular Formula: C₁₈H₂₀ClN₅O₈
• Molecular Weight: 469.83
• Product Categories: Bases & Related Reagents;Nucleotides;Aromatics
• Mol File: 137896-02-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 71-73°C
• Appearance: Light orange solid
• Density: 1.636 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Acetone, Chloroform, Methanol
• PKA: 9.31±0.43(Predicted)
• CAS DataBase Reference: 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE(137896-02-7)
• EPA Substance Registry System: 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE(137896-02-7)

Safety Data

• Hazardous Substances Data: 137896-02-7(Hazardous Substances Data)

Usage

Chemical Properties

Light Orange Solid

Upstream product

• 30747-23-0 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(2-acetylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 16321-99-6 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine 
• 75-05-8 acetonitrile 

Downstream Products

• 288267-81-2 Thiocarbonic acid O-[(2R,3R,3aR,9aR)-2-(2-acetylamino-6-dimethylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester O-phenyl ester 

Relevant articles and documents

Synthesis of N2-alkylguanosine using mitsunobu reaction as a key step

Peracetylated guanosine was reacted with POCl3 to give an 2-acetamido-6-chloro-9H-purine derivative, which was condensed with primary or secondary alcohols to give N2-alkylated analogues. The products were treated with mercaptoethanol in the presence of sodium methoxide to afford N2-alkylguanosines.

Nucleosides and nucleotides. 103. 2-Alkynyladenosines: A novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects

The synthesis and receptor-binding activities at A1 and A2 adenosine receptors for a series of 2-alkynyladenosines are described. The palladium- catalyzed cross-coupling reaction of 2-iodoadenosine (4a) with various terminal alkynes