137898-77-2

Usage

Molecular structure

A complex organic compound with a quinolin-6-ylamine core, a cyclopentylamine group, a 4-amino-phenoxy group, a propyl chain, a methyl group, and various functional and side groups.

Functional groups

Contains an amino group (-NH2) in the 4-amino-phenoxy group and a cyclopentyl-amino (-NH-cyclopentyl) group.

Aromatic rings

The compound has a quinoline ring system and a phenoxy ring system.

Aliphatic chains

A propyl chain connects the 4-amino-phenoxy group to the cyclopentyl-amino group.

Alkyl group

A methyl group (-CH3) is attached to the quinolin-6-ylamine core.

Potential applications

May have applications in medicinal chemistry, particularly in the development of pharmaceuticals targeting specific biological pathways or disease mechanisms.

Further research

Additional studies and analysis are needed to fully understand the properties and potential uses of this chemical compound.

Upstream product

• 613-30-9 2-methyl-6-nitroquinoline 
• 1003-03-8 Cyclopentamine 
• 137898-53-4 N-<3-(4-nitrophenoxy)propyl>cyclopentylamine 
• 76253-89-9 2-methyl-6-nitroquinoline N-oxide 
• 76253-77-5 2-(chloromethyl)-6-nitroquinoline 
• 79096-54-1 1-(3-Chloropropoxy)-4-nitrobenzene 
• 137898-56-7 N-cyclopentyl-6-nitro-N-<(4-nitrophenoxy)propyl>-2-quinolinemethanamine 

Relevant academic research and scientific papers

Synthesis and Selective Class III Antiarrhythmic Activity of Novel N-Heteroaralkyl-Substituted 1-(Aryloxy)-2-propanolamine and Related Propylamine Derivatives

The synthesis and biological evaluation of a series of novel 1-(aryloxy)-2-propanolamines and several related deshydroxy analogues are described.Compounds 4-29 were prepared and investigated for their class III electrophysiological activity in isolated canine Purkinje fibers and in anesthetized open-chest dogs.None of these compounds showed any class I activity.On the basis of the in vitro data, structure-activity relationships for the series are discussed.Two compounds, N-propoxy>phenyl>methanesulfonamide (12, WAY-123,223) and N-phenoxy>propyl>amino>methyl>-6-quinolinyl>methanesulfonamide (24, WAY-125,971) were identified and characterized as potent and specific class III antiarrhythmic agents in vitro and in vivo.Compound 12 was found to be orally bioavailable, to produce large increases of ventricular fibrillation threshold (VFT), and, in some instances, to restore sinus rhythm from ventricular fibrillation in anesthetized open-chest dogs at a dose of 5 mg/kg (iv).The enantiomers of 12 (i.e., 13 and 14) were synthesized and were found to exhibit similar electrophysiological effects in the Purkinje fiber screen.Compound 24, a propylamine analogue with potency and efficacy comparable to those of UK-68798 (2) and E-4031 (3), was studied in voltage-clamp experiments (isolated cat myocytes) and was found to be a potent and specific blocker of the delayed rectifier potassium current (IK).