1379012-29-9

Upstream product

• 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 
• 106-53-6 para-bromobenzenethiol 
• 1605-06-7 (-)-(2S,3S)-2,3-diphenylaziridine 

Downstream Products

• 1379012-50-6 2-((E)-(((1S,2R)-2-((R)-(4-bromophenyl)sulfinyl)-1,2-diphenylethyl)imino)methyl)phenol 
• 1379012-39-1 (1S,2R)-2-((R)-(4-bromophenyl)sulfinyl)-1,2-diphenylethanamine 

Relevant academic research and scientific papers

Chiral sulfide - phosphine ligand and preparation method and use thereof

The present invention provides a novel chiral thioether-phosphine ligand and a preparation method and application thereof. The ligand is a compound shown as a formula I, or enantiomer, non-enantiomer, racemate, pharmaceutically acceptable salt, hydrate and solvate crystal thereof. R1 is an optionally substituted phenyl, and optionally substituted naphthyl; and R2 is methyl and benzyl. The chiral thioether-phosphine ligand provided by the invention as a copper-catalyzed asymmetric cycloaddition ligand can be directly used to prepare various pyrrolidine compounds with substituted multiple chiral centers.

Design of chiral sulfoxide-Schiff base hybrids and their application in Cu-catalyzed asymmetric Henry reactions

A new class of chiral sulfoxide-Schiff base ligands has been developed by the rational combination of two privileged chiral backbones. These sulfoxide-Schiff base ligands were found to be highly efficient for Cu-catalyzed asymmetric Henry reactions (up to