1379038-80-8

Basic information

• Product Name: N-benzylhept-2-yn-1-amine
• Synonyms: N-benzylhept-2-yn-1-amine
• CAS NO: 1379038-80-8
• Molecular Weight: 201.312
• Mol File: 1379038-80-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-benzylhept-2-yn-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzylhept-2-yn-1-amine(1379038-80-8)
• EPA Substance Registry System: N-benzylhept-2-yn-1-amine(1379038-80-8)

Safety Data

• Hazardous Substances Data: 1379038-80-8(Hazardous Substances Data)

Upstream product

• 18495-26-6 1-bromo-2-heptyne 
• 100-46-9 benzylamine 
• 4626-58-8 benzyl(but-2-yn-1-yl)amine 
• 693-02-7 hex-1-yne 
• 1197-51-9 N-propargylbenzylamine 
• 40032-57-3 N-(3-phenylprop-2-ynyl)benzenemethanamine 
• 1273578-50-9 N-benzyl-3-(4-methylphenyl)-2-propynylamine 
• 1610010-33-7 N-benzyl-4,4-dimethylpent-2-yn-1-amine 

Downstream Products

• 1379038-71-7 C₁₉H₂₅NO₄ 
• 1379038-62-6 dimethyl 1-benzyl-3-butyl-4-phenyl-1H-pyrrole-2,2(5H)-dicarboxylate 
• 1379038-60-4 dimethyl 2-[benzyl(hept-3-ynyl)amino]malonate 
• 886433-28-9 oct-1-en-3-yn-2-ylbenzene 
• 795307-39-0 C₁₄H₁₆ 
• 70490-76-5 N-(hept-2-yn-1-yl)aniline 
• 16520-62-0 4-Phenyl-1-butyne 
• 693-02-7 hex-1-yne 
• 1610010-33-7 N-benzyl-4,4-dimethylpent-2-yn-1-amine 

Relevant articles and documents

Lanthanide-Catalyzed Reversible Alkynyl Exchange by Carbon–Carbon Single-Bond Cleavage Assisted by a Secondary Amino Group

Lanthanide-catalyzed alkynyl exchange through C?C single-bond cleavage assisted by a secondary amino group is reported. A lanthanide amido complex is proposed as a key intermediate, which undergoes unprecedented reversible β-alkynyl elimination followed by alkynyl exchange and imine reinsertion. The in situ homo- and cross-dimerization of the liberated alkyne can serve as an additional driving force to shift the metathesis equilibrium to completion. This reaction is formally complementary to conventional alkyne metathesis and allows the selective transformation of internal propargylamines into those bearing different substituents on the alkyne terminus in moderate to excellent yields under operationally simple reaction conditions.

Synthesis of 1,2-disubstituted cyclopentenes by palladium-catalyzed reaction of homopropargyl-substituted dicarbonyl compounds with organic halides via 5- endo-dig cyclization

Palladium catalysts with bulky biaryl phosphine ligands allow homopropargyl-substituted dicarbonyl compounds to undergo intramolecular addition via a rare 5-endo-dig pathway. C-C bond forming reductive elimination follows the addition to introduce alkenyl and alkynyl as well as aryl groups by using the corresponding organic halides. The cyclization is versatile enough to be applicable to the synthesis of highly substituted dihydropyrrole and a fused tricyclic compound.