40032-57-3

Basic information

• Product Name: Benzenemethanamine, N-(3-phenyl-2-propynyl)-
• CAS NO: 40032-57-3
• Molecular Formula: C16H15N
• Molecular Weight: 221.302
• Mol File: 40032-57-3.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, N-(3-phenyl-2-propynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, N-(3-phenyl-2-propynyl)-(40032-57-3)
• EPA Substance Registry System: Benzenemethanamine, N-(3-phenyl-2-propynyl)-(40032-57-3)

Safety Data

• Hazardous Substances Data: 40032-57-3(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 
• 536-74-3 phenylacetylene 
• 4383-22-6 Allylbenzylamine 
• 21541-60-6 3-phenylprop-2-ynyl 4-methylbenzenesulfonate 
• 50-00-0 formaldehyd 
• 1273578-50-9 N-benzyl-3-(4-methylphenyl)-2-propynylamine 
• 1188392-24-6 N-benzyl-N-(3-phenylprop-2-yn-1-yl)prop-2-en-1-amine 
• 4626-58-8 benzyl(but-2-yn-1-yl)amine 
• 3355-31-5 1-chloro-3-phenyl-2-propyne 
• 1197-51-9 N-propargylbenzylamine 
• 591-50-4 iodobenzene 

Downstream Products

• 1351364-94-7 diethyl 1-benzyl-3-phenyl-1H-pyrrole-2,2(5H)-dicarboxylate 
• 1351364-75-4 diethyl 2-(benzyl(3-phenylprop-2-ynyl)amino)malonate 
• 126773-83-9 2-phenyl-5-benzyloxazole 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 1273578-50-9 N-benzyl-3-(4-methylphenyl)-2-propynylamine 
• 536-74-3 phenylacetylene 
• 1379038-80-8 N-benzylhept-2-yn-1-amine 
• 1610010-33-7 N-benzyl-4,4-dimethylpent-2-yn-1-amine 
• 1202222-15-8 N-benzyl-N-(3-phenylprop-2-ynyl)cyanamide 

Relevant articles and documents

Ag-Catalyzed or Ag/PPh3-Catalyzed Chemoselective Switchable Cascade Reactions of N-Propargyl Thiocarbamoyl Fluorides and Malonate Esters

The divergent chemoselective synthesis of 2-methylene-2,3-dihydrothiazoles and 4-benzylidene pyrrolidine-2-thiones (most with E stereoselectivity) from N-propargyl thiocarbamoyl fluorides and malonate esters in moderate to excellent yields with a broad substrate scope and functional group tolerance has been accomplished. AgNTf2 catalyst at 60 °C in dichloroethane provided 4-benzylidene pyrrolidine-2-thiones. AgOTf catalyst and PPh3 ligand in refluxing acetonitrile resulted in a complete switch in the reactivity of formed α,α-diester thioamide intermediates followed by isomerization to access 2-methylene-2,3-dihydrothiazoles.

N-Cyanation of Primary and Secondary Amines with Cyanobenzio-doxolone (CBX) Reagent

An efficient electrophilic N-cyanation of amines with a stable and less-toxic cyanobenziodoxole reagent towards the synthesis of cyanamides is disclosed. This synthetically practicable strategy allows the construction of a wide variety of cyanamides under very mild and simple conditions with a broad functional group compatibility, and showcases a huge potential in late-stage modification of complex molecules.

Palladium-Catalyzed Carbo-Oxygenation of Propargylic Amines using in Situ Tether Formation

1,2-Amino alcohols and α-aminocarbonyls are frequently found in natural products, drugs, chiral auxiliaries, and catalysts. This work reports a new method for the palladium-catalyzed oxyalkynylation and oxyarylation of propargylic amines. The reaction is perfectly regioselective based on the in situ introduction of a hemiacetal tether derived from trifluoroacetaldehyde. cis-Selective carbo-oxygenation was achieved for terminal alkynes, whereas internal alkynes gave trans-carbo-oxygenation products. The obtained enol ethers could be easily transformed into 1,2-amino alcohols or α-amino ketones using hydrogenation or hydrolysis, respectively.