128117-22-6

Basic information

• Product Name: BENZYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE
• Synonyms: BENZYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE;1-Cbz-3-hydroxyazetidine;N-Cbz-3-hydroxyazetidine;3-Hydroxy-azetidine-1-carboxylic acid benzyl ester;1-Azetidinecarboxylic acid 3-hydroxy-, phenylMethyl ester;Phenylmethyl 3-hydroxyazetidine-1-carboxylate;1-Benzyloxycarbonyl-3-hydroxyazetidine;1-N-CBZ-3-HYDROXYAZETIDINE
• CAS NO: 128117-22-6
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.22582
• EINECS: 1308068-626-2
• Mol File: 128117-22-6.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 356.687 °C at 760 mmHg
• Flash Point: 169.5℃
• Appearance: /
• Density: 1.317
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: 2-8°C
• PKA: 14.14±0.20(Predicted)
• CAS DataBase Reference: BENZYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE(128117-22-6)
• EPA Substance Registry System: BENZYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE(128117-22-6)

Safety Data

• Hazardous Substances Data: 128117-22-6(Hazardous Substances Data)

Usage

Description

Benzyl 3-hydroxyazetidine-1-carboxylate is a chemical compound characterized by its molecular formula C13H15NO3. It is a derivative of azetidine, featuring a four-membered heterocyclic ring with one nitrogen atom. Benzyl 3-hydroxyazetidine-1-carboxylate is distinguished by the presence of a benzyl group attached to the azetidine ring, which endows it with stability and versatility for chemical modifications. The 3-hydroxy and carboxylate functional groups further contribute to its potential biological activity and pharmacological properties, making it a multifunctional chemical compound with broad applications in chemistry and medicine.

Uses

Used in Organic Synthesis:
Benzyl 3-hydroxyazetidine-1-carboxylate is utilized as a building block in organic synthesis for its ability to facilitate the creation of complex organic molecules. The benzyl group provides a stable and versatile platform for further chemical modifications, enhancing the compound's utility in the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Benzyl 3-hydroxyazetidine-1-carboxylate is employed as a key intermediate in the development of potential drug candidates. Its unique structure and functional groups make it a promising starting material for the design and synthesis of new pharmaceuticals with potential therapeutic applications.
Used in the Development of Biologically Active Compounds:
Due to its 3-hydroxy and carboxylate functional groups, Benzyl 3-hydroxyazetidine-1-carboxylate is used as a precursor in the synthesis of biologically active compounds. These functional groups can be exploited to create molecules with specific interactions and binding affinities, which are crucial for the development of effective drugs and other bioactive substances.
Overall, Benzyl 3-hydroxyazetidine-1-carboxylate is a versatile and valuable compound in the fields of organic synthesis and pharmaceutical research, with its applications extending to the creation of complex organic molecules and the development of new drug candidates with potential therapeutic benefits.

InChI:InChI=1/C11H13NO3/c13-10-6-12(7-10)11(14)15-8-9-4-2-1-3-5-9/h1-5,10,13H,6-8H2

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 45347-82-8 azetidine-3-ol 
• 18621-18-6 azetion-3-ol hydrochloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 1379079-64-7 benzyl 3-(trifluoromethylsulfonyloxy)azetidine-1-carboxylate 
• 939759-26-9 benzyl 3-iodoazetidine-1-carboxylate 
• 1379079-50-1 benzyl 3-nitroazetidine-1-carboxylate 
• 1379079-51-2 (R)-benzyl 3-((tert-butoxycarbonylamino)(phenyl)methyl)-3-nitroazetidine-1-carboxylate 
• 1379079-52-3 (S)-benzyl 3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)azetidine-1-carboxylate 
• 1434650-42-6 benzyl 3-[(tert-butyldimethylsilyl)oxy]azetidine-1-carboxylate 
• 1311315-85-1 benzyl 3-(chlorosulfonyl)azetidine- 1-carboxylate 
• 1315368-95-6 benzyl 3-[(methylsulfonyl)oxy]azetidine-1-carboxylate 
• 1350607-25-8 benzyl 3-(3-chloropyrazin-2-yloxy)azetidine-1-carboxylate 
• 1093185-36-4 3-oxiranylmethoxyazetidine-1-carboxylic acid benzyl ester 
• 934666-11-2 phenylmethyl 3-[2-(1,3-dioxolan-2-yl)ethylidene]azetidine-1-carboxylate 
• 105258-93-3 N-(Benzyloxycarbonyl)azetidin-3-one 
• 128117-25-9 methyl 2-Benzyl-3-(1-benzyloxycarbonyl-azetidin-3-ylsulfonyl)propionate 
• 128117-24-8 methyl 2-benzyl-3-<<1-(benzyloxycarbonyl)azetidin-3-yl>thio>propionate 

Relevant articles and documents

Fluorescence Assisted Capillary Electrophoresis of Glycans Enabled by the Negatively Charged Auxochromes in 1-Aminopyrenes

A compact and negatively charged acceptor group, N-(cyanamino)sulfonyl, is introduced for dye design and its influence on the absorption and emission spectra of the “push–pull” chromophores is demonstrated with 1,3,6-tris[(cyanamino)sulfonyl]-8-aminopyrene. The new sulfonamides, including O-phosphorylated (3-hydroxyazetidine)-N-sulfonyl, are negatively charged electron acceptors and auxochromes. 1-Aminopyrenes decorated with the new sulfonamides have three or six negative charges (pH ≥8), low m/z ratios, high mobilities in an electric field, and yellow to orange emission. We labeled maltodextrin oligomers by reductive amination, separated the products by electrophoresis, and demonstrated their high brightness in a commercial DNA analyzer and the distribution of the emission signal among the detection channels.

MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a cereblon, Von Hippel-Lindau ligase-binding moiety, Inhibitors of Apotosis Proteins, or mouse double-minute homolog 2 ligand, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS

The invention is concerned with the compounds of formula I and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.