1379175-85-5Relevant academic research and scientific papers
Catalytic asymmetric protonation of chiral calcium enolates via 1,4-addition of malonates
Poisson, Thomas,Yamashita, Yasuhiro,Kobayashi, Shu
supporting information; experimental part, p. 7890 - 7892 (2010/08/05)
Catalytic asymmetric protonation of chiral calcium enolates was performed. Chiral calcium enolates, prepared in situ from imides and malonates via 1,4-addition in the presence of catalytic amounts of Ca(OEt)2, Ph-PyBox, and achiral phenol, were smoothly protonated to afford adducts bearing tertiary asymmetric carbons in high yields with high enantioselectivities. The adducts were readily converted to optically active 2-substituted 1,5-dicarboxylic acid derivatives.
