91368-76-2

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 111119-62-1 Diethyl-methyl-(3-phenyl-prop-2-ynyl)-ammonium; iodide 
• 1794-48-5 1-bromo-3-phenylprop-2-yne 
• 93006-71-4 2-(3-phenylprop-2-ynyl)malonic acid diethyl ester 

Downstream Products

• 3350-92-3 5-phenylpent-4-ynoic acid 
• 109448-38-6 5-phenyl-pent-4-ynoic acid anilide 
• 1379175-85-5 C₁₂H₁₀O₂ 
• 73503-35-2 5-oxo-5-phenyl-valeric acid p-toluidide 
• 4055-00-9 6-phenyl-3,4-dihydropyran-2-one 
• 131107-50-1 5-bromo-5-phenyl-pent-4-enoic acid anilide 
• 131107-49-8 4-bromo-5-phenyl-pent-4-enoic acid anilide 

Relevant academic research and scientific papers

Catalytic asymmetric protonation of chiral calcium enolates via 1,4-addition of malonates

Catalytic asymmetric protonation of chiral calcium enolates was performed. Chiral calcium enolates, prepared in situ from imides and malonates via 1,4-addition in the presence of catalytic amounts of Ca(OEt)2, Ph-PyBox, and achiral phenol, were smoothly protonated to afford adducts bearing tertiary asymmetric carbons in high yields with high enantioselectivities. The adducts were readily converted to optically active 2-substituted 1,5-dicarboxylic acid derivatives.