137934-47-5

Upstream product

• 133995-30-9 (2S,4S)-2-hydroxymethyl-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine 
• 262846-22-0 (2S,4S)-2-(Toluene-4-sulfonyloxymethyl)-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 

Downstream Products

• 262846-15-1 (2S,4S)-2-[4-(Allyloxycarbonylamino-methyl)-phenoxymethyl]-4-mercapto-pyrrolidine-1-carboxylic acid allyl ester 
• 262846-14-0 (2S,4S)-2-[4-(Allyloxycarbonylamino-methyl)-phenylsulfanylmethyl]-4-mercapto-pyrrolidine-1-carboxylic acid allyl ester 
• 262846-19-5 (2S,4S)-4-Mercapto-2-phenylsulfanylmethyl-pyrrolidine-1-carboxylic acid allyl ester 
• 262846-20-8 (2S,4S)-4-Mercapto-2-phenoxymethyl-pyrrolidine-1-carboxylic acid allyl ester 
• 262846-25-3 (2S,4S)-2-Phenoxymethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 262846-26-4 (2S,4S)-2-[4-(Allyloxycarbonylamino-methyl)-phenylsulfanylmethyl]-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 262845-96-5 (2S,4S)-2-[4-(Allyloxycarbonylamino-methyl)-phenoxymethyl]-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 
• 262846-27-5 (2S,4S)-2-Phenylsulfanylmethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester 

Relevant academic research and scientific papers

Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio- 1β-methylcarbapenems. Part 1:J-111,347 and related compounds

1β-Methylcarbapenems having various 3,5-disubstituted pyrrolidinylthio- side chains at C-2 were designed and synthesized. Evaluation of their antibacterial activities indicated that J-111,347 (1a) is the first example of an extremely broad spectrum antibiotic showing activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa.