1379341-83-9Relevant academic research and scientific papers
Quinazoline urea compound as well as preparation method, preparation intermediate, pharmaceutical composition and application
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Paragraph 0379-0382, (2021/06/22)
The invention discloses a quinazoline urea compound as shown in a formula I, and a preparation method, a preparation intermediate, a pharmaceutical composition and application. The structure of the quinazoline urea compound is shown as a formula I, wherein X, Y and substituent groups R1-R9 have meanings provided in the specification. The quinazoline urea compound as shown in the formula I has a good inhibition effect on wild type TrkA/TrkB/TrkC kinase, mutant type TrkA-G595R kinase, mutant type TrkA-G667C kinase, mutant type TrkC-G623R kinase and the like, can be used for preparing medicines for preventing, relieving and/or treating related diseases related to the activity of the Trk kinase, and is especially used for preparing medicines for preventing, relieving and/or treating diseases such as tumors and pains.
QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS
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Paragraph 00295, (2013/03/26)
Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
