137935-38-7

Basic information

• Product Name: Benzenecarbothioic acid, 2,4-dichloro-, S-(4,5-dihydro-5-phenyl-2-thiazolyl) ester
• CAS NO: 137935-38-7
• Molecular Formula: C16H11Cl2NOS2
• Molecular Weight: 368.307
• Mol File: 137935-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenecarbothioic acid, 2,4-dichloro-, S-(4,5-dihydro-5-phenyl-2-thiazolyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarbothioic acid, 2,4-dichloro-, S-(4,5-dihydro-5-phenyl-2-thiazolyl) ester(137935-38-7)
• EPA Substance Registry System: Benzenecarbothioic acid, 2,4-dichloro-, S-(4,5-dihydro-5-phenyl-2-thiazolyl) ester(137935-38-7)

Safety Data

• Hazardous Substances Data: 137935-38-7(Hazardous Substances Data)

Upstream product

• 50-84-0 2,4 dichlorobenzoic acid 
• 1437-98-5 2-mercapto-5-phenylthiazoline 
• 7568-93-6 2-Amino-1-phenylethanol 
• 1437-77-0 sulfuric acid mono-(2-amino-1-phenyl-ethyl) ester 

Relevant articles and documents

Synthesis and Biological Activity of 2-Aminothiazolines and 2-Mercaptothiazolines as Octopaminergic Agonists

2-Aminothiazoline derivatives were synthesized by both hydrochloric acid-catalyzed cyclization of thiourea and cyclization of β-aminoalkyl hydrogen sulfate with isothiocyanate in the presence of sodium hydroxide.Substituted 2-mercaptothiazoline derivatives were prepared by alkylation or acylation of the sodium salt of 2-mercaptothiazoline, which was obtained from β-aminoalkyl hydrogen sulfate with carbon disulfide. 2-(4-Chloro-o-toluidino)-2-thiazoline (III-16) was 33percent as effective as octopamine at 100 μM in stimulating adenylate cyclase of Periplaneta americana ventral-nerve-cord homogenates.Its activity was nonadditive to the activity of octopamine.Stimulation of nerve-cord adenylate cyclase activity by III-16 was inhibited by several antagonists, including mianserin, cyproheptadine, chlorpromazine and gramine.The rank-order ability of these antagonists to block the activation by III-16 was identical to the rank-order ability of the same antagonists to block enzyme activation of octopamine.The β-adrenergic antagonist propanolol was less potent.These data suggest that III-16 is a potent and selctive agonist of octopamine-activated adenylate cyclase.Aminothiazolines which activated adenylate cyclase by 10-87percent relative to octopamine also had acaricidal activity at 300 ppm, indicating a correlation between the in vitro octopaminergic-agonist activity and in vivo acaricidal activity of aminothiazolines.