1437-98-5

Basic information

• Product Name: 5-phenylthiazolidine-2-thione
• Synonyms: 5-phenylthiazolidine-2-thione
• CAS NO: 1437-98-5
• Molecular Formula: C₉H₉NS₂
• Molecular Weight: 0
• Mol File: 1437-98-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 322.2°C at 760 mmHg
• Flash Point: 148.7°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 0.000284mmHg at 25°C
• Refractive Index: 1.7
• CAS DataBase Reference: 5-phenylthiazolidine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenylthiazolidine-2-thione(1437-98-5)
• EPA Substance Registry System: 5-phenylthiazolidine-2-thione(1437-98-5)

Safety Data

• Hazardous Substances Data: 1437-98-5(Hazardous Substances Data)

Usage

General Description

5-Phenylthiazolidine-2-thione is a chemical compound with the molecular formula C9H9NS2. It is a thiazolidine derivative and its structure consists of a thiazolidine ring with a phenyl group attached. 5-phenylthiazolidine-2-thione has been reported to exhibit various biological activities, including antioxidant, antitumor, and antidiabetic properties. It has also been investigated for its potential use in the treatment of inflammation and oxidative stress-related diseases. In addition, 5-phenylthiazolidine-2-thione has been studied for its role as a chelating agent in metal ion complexes, as well as its potential application in the synthesis of pharmaceuticals and agrochemicals. Overall, this chemical compound has shown promising pharmacological and industrial potential due to its unique structure and diverse range of biological activities.

InChI:InChI=1/C9H9NS2/c11-9-10-6-8(12-9)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,10,11)

Upstream product

• 7568-93-6 2-Amino-1-phenylethanol 
• 1499-00-9 2-phenylaziridine 
• 75-15-0 carbon disulfide 
• 96-09-3 styrene oxide 
• 140-89-6 potassium ethyl xanthogenate 
• 52727-47-6 methyl N-1-phenyl-2-iodoethylcarbamate 
• 54898-78-1 (1-chloro-2-isothiocyanato-ethyl)-benzene 
• 1437-77-0 sulfuric acid mono-(2-amino-1-phenyl-ethyl) ester 
• 50835-37-5 2-amino-1-phenyl-ethanol; sulfate (1:1) 
• 7028-48-0 Phenylacetaldehyde oxime 

Downstream Products

• 137935-39-8 2-(ethoxycarbonylmethylmercapto)-5-phenyl-2-thiazoline 
• 137935-38-7 2,4-Dichloro-thiobenzoic acid S-(5-phenyl-4,5-dihydro-thiazol-2-yl) ester 

Relevant articles and documents

Cycloaddition of Aziridine with CO2/CS2 Catalyzed by Amidato Divalent Lanthanide Complexes

This is the first time that the amidato lanthanide amides ({LnLn[N(SiMe3)2]THF}2 (n = 1, Ln = Eu (1); n = 2, Ln = Eu (3), Yb (4); HL1 = tBuC6H4CONHC6H3(iPr)2; HL2 = C6H5CONHC6H3(iPr)2) and {L3Eu[N(SiMe3)2]THF}{L32Eu(THF)2} (2) (HL3 = ClC6H4CONHC6H3(iPr)2)) were applied in the cycloaddition reactions of aziridines with carbon dioxide (CO2) or carbon disulfide (CS2) under mild conditions. The corresponding oxazolidinones and thiazolidine-2-thiones were obtained in good to excellent yields with good functional group tolerance.

Synthesis and Biological Activity of 2-Aminothiazolines and 2-Mercaptothiazolines as Octopaminergic Agonists

2-Aminothiazoline derivatives were synthesized by both hydrochloric acid-catalyzed cyclization of thiourea and cyclization of β-aminoalkyl hydrogen sulfate with isothiocyanate in the presence of sodium hydroxide.Substituted 2-mercaptothiazoline derivatives were prepared by alkylation or acylation of the sodium salt of 2-mercaptothiazoline, which was obtained from β-aminoalkyl hydrogen sulfate with carbon disulfide. 2-(4-Chloro-o-toluidino)-2-thiazoline (III-16) was 33percent as effective as octopamine at 100 μM in stimulating adenylate cyclase of Periplaneta americana ventral-nerve-cord homogenates.Its activity was nonadditive to the activity of octopamine.Stimulation of nerve-cord adenylate cyclase activity by III-16 was inhibited by several antagonists, including mianserin, cyproheptadine, chlorpromazine and gramine.The rank-order ability of these antagonists to block the activation by III-16 was identical to the rank-order ability of the same antagonists to block enzyme activation of octopamine.The β-adrenergic antagonist propanolol was less potent.These data suggest that III-16 is a potent and selctive agonist of octopamine-activated adenylate cyclase.Aminothiazolines which activated adenylate cyclase by 10-87percent relative to octopamine also had acaricidal activity at 300 ppm, indicating a correlation between the in vitro octopaminergic-agonist activity and in vivo acaricidal activity of aminothiazolines.

On a transposition of cyclic ammonium observed in the synthesis of 2-thio-thiazolidones.

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