1437-98-5

Usage

Uses

Used in Pharmaceutical Industry:
5-Phenylthiazolidine-2-thione is used as a pharmaceutical candidate for its antioxidant, antitumor, and antidiabetic properties, offering potential therapeutic benefits in the treatment of various diseases and conditions.
Used in Medical Research:
As an agent with potential anti-inflammatory and disease-treating capabilities, 5-phenylthiazolidine-2-thione is used in research for the development of treatments targeting inflammation and oxidative stress-related diseases.
Used in Chemical Synthesis:
5-Phenylthiazolidine-2-thione is utilized as a chelating agent in metal ion complexes, which can be important in various chemical processes and applications.
Used in Agrochemical Industry:
5-phenylthiazolidine-2-thione is also considered for its potential application in the synthesis of agrochemicals, indicating its versatility beyond the pharmaceutical sector.
Used in Material Science:
Given its unique structure and properties, 5-phenylthiazolidine-2-thione may also find use in material science for the development of new materials with specific characteristics.

InChI:InChI=1/C9H9NS2/c11-9-10-6-8(12-9)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,10,11)

Upstream product

• 75-15-0 carbon disulfide 
• 7028-48-0 Phenylacetaldehyde oxime 
• 50835-37-5 2-amino-1-phenyl-ethanol; sulfate (1:1) 
• 1437-77-0 sulfuric acid mono-(2-amino-1-phenyl-ethyl) ester 
• 140-89-6 potassium ethyl xanthogenate 
• 54898-78-1 (1-chloro-2-isothiocyanato-ethyl)-benzene 
• 7568-93-6 2-Amino-1-phenylethanol 
• 1499-00-9 2-phenylaziridine 
• 96-09-3 styrene oxide 
• 52727-47-6 methyl N-1-phenyl-2-iodoethylcarbamate 

Downstream Products

• 137935-39-8 2-(ethoxycarbonylmethylmercapto)-5-phenyl-2-thiazoline 
• 137935-38-7 2,4-Dichloro-thiobenzoic acid S-(5-phenyl-4,5-dihydro-thiazol-2-yl) ester 

Relevant academic research and scientific papers

Cycloaddition of Aziridine with CO2/CS2 Catalyzed by Amidato Divalent Lanthanide Complexes

This is the first time that the amidato lanthanide amides ({LnLn[N(SiMe3)2]THF}2 (n = 1, Ln = Eu (1); n = 2, Ln = Eu (3), Yb (4); HL1 = tBuC6H4CONHC6H3(iPr)2; HL2 = C6H5CONHC6H3(iPr)2) and {L3Eu[N(SiMe3)2]THF}{L32Eu(THF)2} (2) (HL3 = ClC6H4CONHC6H3(iPr)2)) were applied in the cycloaddition reactions of aziridines with carbon dioxide (CO2) or carbon disulfide (CS2) under mild conditions. The corresponding oxazolidinones and thiazolidine-2-thiones were obtained in good to excellent yields with good functional group tolerance.

Synthesis and Fungicidal Activity of Simple Structural 1,3-Thiazolidine-2-Thione Derivatives

A series of simple structural 1,3-thiazolidine-2-thione derivatives with various substituents on the S-, N-, 4-, and 5-positions was synthesized with high yields from various vicinal amino alcohols via two steps and screened for their antifungal activity. Bioassay results reveal that some thiazolidine-2-thione derivatives show strong antifungal activities against P. capsici, G. zeae, S. sclerotiorum, A. alternata, B. cinerea, or R. solani. The SAR analysis indicates that N-acyl substituted and 4-alkyl substituents can enhance the antifungal activity. Notably, 4-isopropyl-N-propionylthiazoldine-2-thione shows excellent activity against B. cinerea and G. zeae with IC50 values at 3.7 g/mL and 6.5 g/mL, respectively, and 4-isobutyl-N-propionylthiazoldine-2-thione shows remarkable fungicidal activity against R. solani, S. sclerotiorum, and G. zeae with IC50 values at 1.0 g/mL, 12.1 g/mL, and 11.0 g/mL, respectively. GRAPHICAL ABSTRACT.

Synthesis and Biological Activity of 2-Aminothiazolines and 2-Mercaptothiazolines as Octopaminergic Agonists

2-Aminothiazoline derivatives were synthesized by both hydrochloric acid-catalyzed cyclization of thiourea and cyclization of β-aminoalkyl hydrogen sulfate with isothiocyanate in the presence of sodium hydroxide.Substituted 2-mercaptothiazoline derivatives were prepared by alkylation or acylation of the sodium salt of 2-mercaptothiazoline, which was obtained from β-aminoalkyl hydrogen sulfate with carbon disulfide. 2-(4-Chloro-o-toluidino)-2-thiazoline (III-16) was 33percent as effective as octopamine at 100 μM in stimulating adenylate cyclase of Periplaneta americana ventral-nerve-cord homogenates.Its activity was nonadditive to the activity of octopamine.Stimulation of nerve-cord adenylate cyclase activity by III-16 was inhibited by several antagonists, including mianserin, cyproheptadine, chlorpromazine and gramine.The rank-order ability of these antagonists to block the activation by III-16 was identical to the rank-order ability of the same antagonists to block enzyme activation of octopamine.The β-adrenergic antagonist propanolol was less potent.These data suggest that III-16 is a potent and selctive agonist of octopamine-activated adenylate cyclase.Aminothiazolines which activated adenylate cyclase by 10-87percent relative to octopamine also had acaricidal activity at 300 ppm, indicating a correlation between the in vitro octopaminergic-agonist activity and in vivo acaricidal activity of aminothiazolines.

STEREOSPECIFIC SYNTHESIS OF THIAZOLIDINE-2-THIONES

The synthesis of thiazolidine-2-thiones from vic-iodoalkanecarbamates, stereospecifically obtained from cis and trans-butene, is reported.Reaction of the iodo-derivatives with potassium ethylxanthate and sodium hydroxide, allowed the stereospecific format