1379427-96-9

Basic information

• Product Name: 1-(2-bromo-4-chlorophenyl)-N-hydroxymethanimine
• Synonyms: 1-(2-bromo-4-chlorophenyl)-N-hydroxymethanimine
• CAS NO: 1379427-96-9
• Molecular Weight: 234.48
• Mol File: 1379427-96-9.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-4-chlorophenyl)-N-hydroxymethanimine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-4-chlorophenyl)-N-hydroxymethanimine(1379427-96-9)
• EPA Substance Registry System: 1-(2-bromo-4-chlorophenyl)-N-hydroxymethanimine(1379427-96-9)

Safety Data

• Hazardous Substances Data: 1379427-96-9(Hazardous Substances Data)

Upstream product

• 84459-33-6 2-bromo-4-chlorobenzaldehyde 

Downstream Products

• 1620919-40-5 3-(2-bromo-4-chlorophenyl)-5-phenyl-4,5-dihydroisoxazole 
• 57381-49-4 2-bromo-4-chloro-benzonitrile 
• 958-69-0 2-(2-bromo-4-chlorophenyl)quinoline 

Relevant articles and documents

One-pot synthesis of isoxazolines from aldehydes catalyzed by iodobenzene

A convenient one-pot, three-step procedure for the synthesis of isoxazolines starting from aldehydes has been developed involving catalytic cycloaddition between nitrile oxides and alkenes, in which iodobenzene is used as the catalyst for the in situ generation of a hypervalent iodine intermediate. In this approach, the aldehydes are first transformed with hydroxylamine sulfate into aldoximes, which are then oxidized to nitrile oxides by the in situ generated hypervalent iodine intermediate; finally, a 1,3-dipolar cycloaddition between the nitrile oxides and alkenes occurs to provide the isoxazolines in moderate to good yields.

Discovery of Natural Product-Based Fungicides (II): Semisynthesis and Biological Activity of Sarisan Attached 3-Phenylisoxazolines as Antifungal Agents

Many phytopathogenic fungi cause severe damage to crop yields. In continuation of our research aimed at the discovery and development of natural products-based fungicides, a series of thirty-one sarisan attached 3-phenylisoxazolines were synthesized and evaluated for their antifungal activities against five phytopathogenic fungi (B. cinerea, C. lagenarium, A. solani, F. solani, and F. graminearum). Among all title sarisan derivatives, compounds IV2, IV14 and IV23 showed potent antifungal activity against some phytopathogenic fungi. In particular, compound IV2 exhibited a broad-spectrum and more potent antifungal activity against A. solani, F. solani, and F. graminearum than the commercial fungicide Hymexazol. In addition, compounds IV2, IV14 and IV23 also displayed relative low toxicity on normal NRK-52E cells. This work will give some insights into the development of sarisan derivatives as new fungicide candidates in plant protection.

A radical cyclization cascade of 2-alkynylbenzonitriles with sodium arylsulfinates

A convenient radical cyclization cascade procedure for the construction of sulfonated indenones from 2-alkynylbenzonitriles and sodium arylsulfinates has been explored under mild reaction conditions. The present methodology offers a low-cost and operationally straightforward approach to synthesizing various sulfonated indenones in moderate to good yields by simple use of cheap sodium persulfate as an oxidant and environmentally benign water as a co-solvent.

SUBSTITUTED OXOPYRIDINE DERIVATIVES

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and o edemas, and also ophthalmic disorders.