958-69-0Relevant academic research and scientific papers
Enantioselective Dearomative [3 + 2] Umpolung Annulation of N-Heteroarenes with Alkynes
Cui, Bing-Hui,Huang, Wen-Yu,Jia, Yi-Xia,Liang, Ren-Xiao,Liu, Hang,Liu, Jia-Liang,Wang, Qiang,Yang, Peng,Zhang, Xiao-Dong,Zhang, Yue-Yuan
, p. 1087 - 1093 (2022/02/09)
Enantioselective [3 + 2] annulation of N-heteroarenes with alkynes has been developed via a cobalt-catalyzed dearomative umpolung strategy in the presence of chiral ligand and reducing reagent. A variety of electron-deficient N-heteroarenes, including qui
A Novel Route to 2-Arylquinolines: Reductive Cleavage of 2′-Nitroaryl-Δ2 -isoxazolines
Kamath, Prashantha,Viner, Russell C.,Smith, Stephen C.,Lal, Mukul
, p. 1341 - 1345 (2017/06/27)
A novel synthetic route for the synthesis of quinolines starting from Δ 2 -isoxazolines under reductive conditions is reported. The reductive cyclization to quinolines is achieved under both metal and metal-free conditions. The reaction proceeds via an intramolecular N-H?O hydrogen bond intermediate, accelerating the reductive cleavage 1000-fold (DFT calculations) in comparison with non-hydrogen bonded system.
