1379445-46-1

Upstream product

• 93-91-4 1-phenylbutan-1,3-dione 
• 1379445-77-8 3-benzoyl-4-oxopentanoic acid tert-butyl ester 
• 1322082-29-0 tert-Butyl (5-methyl-3-phenyl-1H-pyrazol-4-yl)acetate 
• 1379445-86-9 tert-Butyl {5-methyl-3-phenyl-1-[2-(phenylsulfonyl)benzyl]-1H-pyrazol-4-yl}-acetate 

Relevant academic research and scientific papers

2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists

High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.

NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

New pyrazole derivatives having CRTh2 antagonistic behaviour

The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.