1379446-01-1Relevant academic research and scientific papers
2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists
Andrés, Miriam,Bravo, Mónica,Buil, Maria Antonia,Calbet, Marta,Castro, Jordi,Domènech, Teresa,Eichhorn, Peter,Ferrer, Manel,Gómez, Elena,Lehner, Martin D.,Moreno, Imma,Roberts, Richard S.,Sevilla, Sara
, p. 3349 - 3353 (2013/06/27)
High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.
New pyrazole derivatives having CRTh2 antagonistic behaviour
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Page/Page column 35, (2012/06/05)
The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR
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Page/Page column 54-55, (2012/06/15)
The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
