1379462-82-4

Basic information

• Product Name: (E)-3-ethoxy-3-oxoprop-1-enylboronic acid
• Synonyms: (E)-3-ethoxy-3-oxoprop-1-enylboronic acid;(E)-(3-Ethoxy-3-oxoprop-1-en-1-yl)boronic acid
• CAS NO: 1379462-82-4
• Molecular Formula: C5H9BO4
• Molecular Weight: 143.93356
• Mol File: 1379462-82-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-3-ethoxy-3-oxoprop-1-enylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-ethoxy-3-oxoprop-1-enylboronic acid(1379462-82-4)
• EPA Substance Registry System: (E)-3-ethoxy-3-oxoprop-1-enylboronic acid(1379462-82-4)

Safety Data

• Hazardous Substances Data: 1379462-82-4(Hazardous Substances Data)

Usage

General Description

(E)-3-ethoxy-3-oxoprop-1-enylboronic acid, also known as Ethyl propiolylboronic acid, is a chemical compound with the molecular formula C6H9BO4. It is a boronic acid derivative and a key intermediate in the synthesis of pharmaceuticals and organic compounds. (E)-3-ethoxy-3-oxoprop-1-enylboronic acid is used in organic synthesis as a reagent for the preparation of 1,3-enynes and as a precursor for the synthesis of a wide range of biologically active compounds. It is also used as a ligand in palladium-catalyzed cross-coupling reactions and as a reactant in the preparation of organoboron compounds for medicinal chemistry research. Ethyl propiolylboronic acid is a versatile and valuable chemical compound with a wide range of applications in organic synthesis and pharmaceutical research.

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Relevant articles and documents

Cobalt-Catalyzed Diastereo- and Enantioselective Hydroalkenylation of Cyclopropenes with Alkenylboronic Acids

Catalytic diastereo- and enantioselective hydroalkenylation of 3,3-disubstituted cyclopropenes with readily accessible alkenylboronic acids, promoted by a chiral phosphine/Co complex, is presented. Such a process constitutes the unprecedented and direct i

Copper-Catalyzed Oxy-Alkenylation of Homoallylic Alcohols to Generate Functional syn-1,3-Diol Derivatives

A novel method for the synthesis of a wide range of functionalized 1,3-diol derivatives is reported. Employing a copper-catalyzed oxy-alkenylation strategy, a range of readily available, substituted homoallylic alcohol derivatives and alkenyl(aryl) iodonium salts combine to form syn-1,3-carbonates in excellent yield and with high selectivity. Furthermore, the products formed are amenable to an iterative reaction sequence, thus affording highly complex polyketide-like fragments. Polyols: The reported copper-catalyzed oxy-alkenylation strategy works well for a range of readily available, substituted homoallylic alcohol derivatives and alkenyl(aryl) iodonium salts to form syn-1,3-carbonates in excellent yield and high selectivity. Furthermore, the products formed are amenable to an iterative reaction sequence, thus affording highly complex polyketide-like fragments.