13795-44-3Relevant academic research and scientific papers
Use of polymer-bound 4-dialkylaminopyridines in peptide synthesis
Frontin, F. Cavelier,Guendouz, F.,Jacquier, R.,Verducci, J.
, p. 463 - 467 (2007/10/02)
This work describes the use of polymer-bound 4-dialkylaminopyridines as catalyst in peptide bond formation.In comparison with their soluble analogues, such as DMAP, these less basic compounds are less favorable to formation of oxazolone intermediate, and lead to peptide bond formation in good yields, and generally very low racemization. Key words: DMAP; polymer-bound dialkylaminopyridines; peptide synthesis; racemization.
