1379511-48-4

Basic information

• Product Name: C₂₁H₃₀N₆O₄
• CAS NO: 1379511-48-4
• Molecular Weight: 430.507
• Mol File: 1379511-48-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₃₀N₆O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₃₀N₆O₄(1379511-48-4)
• EPA Substance Registry System: C₂₁H₃₀N₆O₄(1379511-48-4)

Safety Data

• Hazardous Substances Data: 1379511-48-4(Hazardous Substances Data)

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 68498-54-4 isocyanocyclopentane 
• 146651-75-4 tert–butyl (2–aminophenyl)carbamate 

Relevant articles and documents

Concise route to a series of novel 3-(tetrazol-5-yl)quinoxalin-2(1H)-ones

This Letter presents a novel three step solution phase protocol to synthesize 3-(tetrazol-5-yl)quinoxalin-2(1H)-ones. The strategy utilizes ethyl glyoxalate and mono-N-Boc-protected-o-phenylenediamine derivatives in the Ugi-Azide multi-component reaction (MCR) to generate a unique 1,5-disubstituted tetrazole. Subsequent acid treatment stimulates a simultaneous Boc deprotection and intramolecular cyclization leading to bis-3,4-dihydroquinoxalinone tetrazoles. Direct oxidation using a stable solid-phase radical catalyst (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) with ceric ammonium nitrate (CAN) in catalytic fashion initiating aerobic oxidation, completes the entire procedure to generate a series of original unique bis-quinoxalinone tetrazoles. The method was also expanded to produce a bis-benzodiazepine tetrazole.