137958-85-1

Basic information

• Product Name: N,N-diethyl-2-(4-methoxyphenyl)acrylamide
• Synonyms: N,N-diethyl-2-(4-methoxyphenyl)acrylamide
• CAS NO: 137958-85-1
• Molecular Weight: 233.31
• Mol File: 137958-85-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-2-(4-methoxyphenyl)acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-(4-methoxyphenyl)acrylamide(137958-85-1)
• EPA Substance Registry System: N,N-diethyl-2-(4-methoxyphenyl)acrylamide(137958-85-1)

Safety Data

• Hazardous Substances Data: 137958-85-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 115348-15-7 N,N-diethyl-2-(4-methoxyphenyl)acetamide 
• 104-01-8 4-Methoxyphenylacetic acid 
• 201230-82-2 carbon monoxide 
• 121-44-8 triethylamine 
• 768-60-5 4-methoxyphenylacetylen 
• 109-89-7 diethylamine 

Downstream Products

• 1507347-43-4 (Z)-N,N-diethyl-4,4,4-trifluoro-2-(4-methoxyphenyl)but-2-enamide 

Relevant articles and documents

Palladium-Catalyzed Hydroaminocarbonylation of Alkynes with Tertiary Amines via C-N Bond Cleavage

An efficient strategy for the cleavage of the C-N bond of tertiary amines was developed with DTBP as an oxidant, in which the cleaved H atom and amine moiety were successfully transferred to the desired products. This strategy has enabled an efficient palladium-catalyzed hydroaminocarbonylation of alkynes with tertiary amines. Notably, the catalyst loading could be lowered from 5 to 0.1 mol %, which represents the lowest catalyst loading among the reported work on carbonylation via C-N bond activation.

Organic Iodide Aided Carbonylation of Terminal Acetylenes with Palladium Catalyst

Carbonylation of various terminal acetylenes in the presence of a catalytic amount of organic iodides or amine * HI salt and palladium complexes was found to produce 2-substituted acrylamides in good yields under mild conditions (5 atm, 120 deg C, 6h).