1379588-33-6Relevant articles and documents
Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities Dedicated to Professor Jean Marie Coustard, a creative chemist
El Bahhaj, Fatima,Désiré, Jér?me,Blanquart, Christophe,Martinet, Nadine,Zwick, Vincent,Sim?es-Pires, Claudia,Cuendet, Muriel,Grégoire, Marc,Bertrand, Philippe
, p. 9702 - 9708 (2014)
An innovative synthesis of psammaplin-like structure is proposed based on original methodologies using superacid, microwaves, and S-ene chemistry. The new compounds were evaluated as histone deacetylase inhibitors. The results highlight important consider
Synthesis of Air- and Moisture-Stable, Storable Chiral Oxorhenium Complexes and Their Application as Catalysts for the Enantioselective Imine Reduction
Das, Braja Gopal,Nallagonda, Rajender,Dey, Dhananjay,Ghorai, Prasanta
supporting information, p. 12601 - 12605 (2015/09/01)
Air-/moisture-stable, crystalline, and storable chiral salicyloxazoline based oxorhenium(V) complexes have been synthesized and their catalytic application for the asymmetric reduction of ketimines using hydrosilane as hydride source is disclosed. A broad substrate scope, high yields, and excellent enantioselectivities (up to 99 %) are attained. Furthermore, the syntheses of enantiopure α-amino esters, γ- and δ-lactams, and isoindolinones have also been carried out using this methodology. Finally, the method has been applied to synthetic targets of pharmaceutical relevance, such as R-(+)-salsolidine and R-(+)-crispine A.
