1379597-75-7

Upstream product

• 137000-66-9 1,4-diethynyl-2-fluorobenzene 
• 75676-72-1 2-chloro-4-iodo-1-methoxybenzene 
• 1379597-73-5 (E,E)-1-fluoro-2,5-bis(3-methoxy[⁽¹³⁾C]carbonyl-4-methoxystyryl)benzene 
• 1379597-71-3 (E,E)-1-fluoro-2,5-bis(3-chloro-4-methoxystyryl)benzene 

Downstream Products

• 1379597-77-9 (E,E)-1-fluoro-2,5-bis-(3-hydroxy[⁽¹³⁾C]carbonyl-4-hydroxystyryl)benzene 

Relevant academic research and scientific papers

Isotope-labeling of the fibril binding compound FSB via a Pd-catalyzed double alkoxycarbonylation

We have synthesized two isotopically labeled variants of the β-amyloid binding compound FSB possessing 13C-labels on the two terminal aryl carboxylic acid moieties. One of these was also fully deuterated on the olefinic spacers. The 13C-isotope labeling was achieved applying a Pd-catalyzed methoxycarbonylation of the corresponding aryl chlorides with externally (ex situ) generated 13C-labeled CO. Application of the Shirakawa-Hayashi protocol for the Pd-catalyzed reduction of a dialkyne intermediate using D2O allowed for the selective deuterium labeling of the two trans-C,C double bonds of FSB.