137960-07-7Relevant academic research and scientific papers
Studies toward diazonamide A: Initial synthetic forays directed toward the originally proposed structure
Nicolaou,Snyder, Scott A.,Huang, Xianhai,Simonsen, Klaus B.,Koumbis, Alexandros E.,Bigot, Antony
, p. 10162 - 10173 (2007/10/03)
A brief introduction into the chemistry of diazonamide A (1) is followed by first-generation sequences to access the originally proposed structure for this unusual marine natural product. These explorations identified a route capable of delivering a model compound possessing the complete heteroaromatic core of the natural product, highlighting in the process several unanticipated synthetic challenges which led both to new methodology as well as an improved synthetic plan that was successfully applied to fully functionalized intermediates.
Synthesis of oxazolidine derivatives of β-[3-(aryloxy)aryl]-α-amino acids by application of the diels-alder reaction
Olsen, Richard K.,Feng, Xianqi
, p. 5721 - 5724 (2007/10/02)
The Diels-Alder reaction has been used to construct the diaryl ether unit in oxazolidine derivatives of β-[3-(aryloxy)aryl]-α-amino acids. Cycloaddition of acetylenic ketone 6 with substituted aryloxy dienes, and subsequent aromatization, provided the tit
