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Carbamic acid, [2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, phenylmethyl ester, (S)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • Carbamic acid, [2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, phenylmethyl ester, (S)-

    Cas No: 115424-05-0

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  • 115424-05-0 Structure
  • Basic information

    1. Product Name: Carbamic acid, [2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, phenylmethyl ester, (S)-
    2. Synonyms:
    3. CAS NO:115424-05-0
    4. Molecular Formula: C18H21NO4
    5. Molecular Weight: 315.369
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 115424-05-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Carbamic acid, [2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, phenylmethyl ester, (S)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Carbamic acid, [2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, phenylmethyl ester, (S)-(115424-05-0)
    11. EPA Substance Registry System: Carbamic acid, [2-hydroxy-1-[(4-methoxyphenyl)methyl]ethyl]-, phenylmethyl ester, (S)-(115424-05-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 115424-05-0(Hazardous Substances Data)

115424-05-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 115424-05-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,4,2 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 115424-05:
(8*1)+(7*1)+(6*5)+(5*4)+(4*2)+(3*4)+(2*0)+(1*5)=90
90 % 10 = 0
So 115424-05-0 is a valid CAS Registry Number.

115424-05-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-2-(benzyloxycarbonylamino)-3-(4-methoxyphenyl)-1-propanol

1.2 Other means of identification

Product number -
Other names N-benzyloxycarbonyl-O-methyl-S-tyrosinol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115424-05-0 SDS

115424-05-0Relevant articles and documents

Synthesis of Water-Soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers and Circularly Polarized Luminescence

Dai, Lixiong,Zhang, Junhui,Chen, Yuqing,Mackenzie, Lewis E.,Pal, Robert,Law, Ga-Lai

, p. 12506 - 12510 (2019)

One-step cyclization of a tetraazamacrocycle 5 with 70% yield in a 25-g scale was performed. Its chiral DOTA derivatives, L4, has ?93% of TSAP coordination isomer in its Eu(III) and Yb(III) complexes in aqueous solution. [GdL4]5- exhibits a high relaxivity, making it a promising and efficient MRI contrast agent. High luminescence dissymmetry factor (glum) values of 0.285 (ΔJ = 1) for [TbL3]- and 0.241 (ΔJ = 1) for [TbL4]5- in buffer solutions were recorded.

CHIRAL CYCLEN COMPOUNDS AND THEIR USES

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Paragraph 0091; 0195, (2018/04/13)

The present invention relates to the preparation of a series of chiral DOTA, D03A, D02A, DO1A, cyclen and their metal complexes, which display properties superior to those of previous DOTA- based compounds, and hence are potentially valuable as a platform for diagnostic applications. The chiral DOTAs reveal a high abundance of twisted square antiprism (TSA) geometry favoring them to be used as potential MRI contrast agents, whereas their rapid labelling properties at mild conditions make them excellent candidates for use as radiometal chelators.

Asymmetric synthesis of unnatural amino acids and tamsulosin chiral intermediate

Arava, Veera Reddy,Amasa, Srinivasulu Reddy,Goud Bhatthula, Bharat Kumar,Kompella, Laxmi Srinivas,Matta, Venkata Prasad,Subha

, p. 2892 - 2897 (2013/09/02)

An efficient and enantioselective hydrogenation of N-acetylamino phenyl acrylic acids was successfully developed by using ruthenium catalyst. This methodology is important in the field of pharmaceuticals and provides a new process for the preparation of unnatural amino acids and tamsulosin chiral intermediate.

Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor

Bosch, M. Pilar,Campos, Francisco,Niubó, Itziar,Rosell, Gloria,Díaz, J. Luis,Brea,Loza, M. Isabel,Guerrero, Angel

, p. 4041 - 4053 (2007/10/03)

New adenosine derivatives have been synthesized and tested as putative agonists of adenosine receptors. Compounds 2-6 derive from the introduction of several types of substituents (electron donating, electron withdrawing, and halogens) in the para-position of the phenyl ring of the parent compound 1, and compound 7 lacks the hydroxyl group of amino alcohol 1. In radioligand binding assays using recombinant human A1, A2A, A2B, and A3 receptors, all compounds showed very low or negligible affinity for A1 and A2B receptors but compounds 3, 5, and 7 displayed a remarkably potent affinity for the A2A receptor with Ki values of 1-5 nM. Bromo derivative 3 displayed a selectivity A1/A2A = 62 and A3/A2A = 16 whereas the presence of a hydroxyl group (compound 5) improved the selectivity of A 1/A2A and A3/A2A to 120- and 28-fold, respectively. When the methoxy derivative 4 lacks the hydroxyl group on the side chain (compound 7), the binding affinity for A2A is increased to 1 nM, improving selectivity ratios to 356- and 100-fold against A1 and A3, respectively. In Chinese hamster ovary cells transfected with human A2A and A2B receptors, most compounds showed a remarkable activity for the A2A receptor, except chloro derivative 2, with EC50 values ranging from 1.4 to 8.8 nM. The compounds behaved as good A2A agonists, and all were more selective than 5′-(N-ethylcarboxamino)adenosine (NECA), with A2B/A 2A ratios of cAMP accumulation ranging from 48 for compound 2 to 666 for compound 7 while the corresponding A2B/A2A ratio for NECA was only 9. Compounds 1, 3, 5, and 7 also displayed higher selectivities than NECA up to 100-fold in isolated aortas of rat and guinea pig. In guinea pig tracheal rings precontracted by carbachol, compounds 2 and 4 were more potent than adenosine (100-fold) and NECA (10-fold), whereas compounds I and 7 displayed similar effects to NECA. Pretreatment of the tracheal rings with A2, A2A, and A2B receptor antagonists 3,7-dimethyl-L-propargylxanthine, 8-(3-chlorostyryl)caffeine, and alloxazine produced a marked inhibition of the tracheal relaxations induced by compounds 1, 2, and 4, but none of the compounds showed selectivity toward any of the adenosine receptors.

HYDROXYMORPHOLINONE DERIVATIVE AND MEDICINAL USE THEREOF

-

Page 16, (2010/02/09)

A compound represented by the following formula (I) wherein R1 and R2 are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof is provided.

Novel 6-Hydroxy-3-morpholinones as cornea permeable calpain inhibitors

Nakamura, Masayuki,Miyashita, Hiroyuki,Yamaguchi, Masazumi,Shirasaki, Yoshihisa,Nakamura, Yoshikuni,Inoue, Jun

, p. 5449 - 5460 (2007/10/03)

A novel series of 6-hydroxy-3-morpholinones, in which the functional aldehyde and the hydroxy group of P2 site form a cyclic hemiacetal, was identified as calpain inhibitors. The placement of isobutyl group at the 2-position of the 3-morpholino

Syntheses of amino alcohols and chiral C2-symmetric bisoxazolines derived from O-alkylated R-4-hydroxyphenylglycine and S-tyrosine

Caplar, Vesna,Raza, Zlata,Katalenic, Darinka,Zinic, Mladen

, p. 23 - 36 (2007/10/03)

Chiral C2-symmetric bisoxazolines 1b-f and 2b,c, derived from 4′-O-alkylated R-4-hydroxyphenylglycine or S-tyrosine, were prepared. As intermediates, a series of chiral amino alcohols possessing substituted phenolic groups was prepared and fully characterized.

Effective and mild method for preparation of optically active α-amino aldehydes via TEMPO oxidation

Jurczak, Janusz,Gryko, Dorota,Kobrzycka, Elzbieta,Gruza, Henryk,Prokopowicz, Piotr

, p. 6051 - 6064 (2007/10/03)

The TEMPO oxidation method is successfully applied to preparation of variously protected, optically active α-amino aldehydes without racemization and in very good yield.

A simple and efficient procedure for the synthesis of optically active 4-methoxy-α-methylphenylethylamine from tyrosine

Kohno, Harumichi,Iwakuma, Takeo,Yamada, Koichiro

, p. 1935 - 1945 (2007/10/03)

Optically active 4-methoxy-α-methylphenylethylamine (1), a useful chiral building block in medicinal chemistry, was synthesized from L- or D- tyrosine by using a simple and efficient procedure via one-pot zinc reduction of the corresponding O-tosylate (4) in the presence of H2O and NaI in pure form.

Synthesis of oxazolidine derivatives of β-[3-(aryloxy)aryl]-α-amino acids by application of the diels-alder reaction

Olsen, Richard K.,Feng, Xianqi

, p. 5721 - 5724 (2007/10/02)

The Diels-Alder reaction has been used to construct the diaryl ether unit in oxazolidine derivatives of β-[3-(aryloxy)aryl]-α-amino acids. Cycloaddition of acetylenic ketone 6 with substituted aryloxy dienes, and subsequent aromatization, provided the tit

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