1379648-87-9Relevant academic research and scientific papers
Enzyme-triggered gelation: Targeting proteases with internal cleavage sites
Bremmer, Steven C.,McNeil, Anne J.,Soellner, Matthew B.
, p. 1691 - 1693 (2014)
A generalizable method for detecting protease activity via gelation is described. A recognition sequence is used to target the protease of interest while a second protease is used to remove the residual residues from the gelator scaffold. Using this appro
A general method for detecting protease activity via gelation and its application to artificial clotting
Bremmer, Steven C.,Chen, Jing,McNeil, Anne J.,Soellner, Matthew B.
supporting information; experimental part, p. 5482 - 5484 (2012/07/28)
A modular system for detecting protease activity via enzyme-triggered gel formation is described. Protease-specific recognition sequences are utilized to achieve enzyme specificity. Artificial blood clotting is demonstrated by activating endogenous thrombin to trigger gelation in fibrinogen-deficient blood plasma.
