1379655-82-9Relevant academic research and scientific papers
Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase
Soares Da Costa, Tatiana P.,Tieu, William,Yap, Min Y.,Zvarec, Ondrej,Bell, Jan M.,Turnidge, John D.,Wallace, John C.,Booker, Grant W.,Wilce, Matthew C. J.,Abell, Andrew D.,Polyak, Steven W.
, p. 509 - 514 (2012)
There is a desperate need to develop new antibiotic agents to combat the rise of drug-resistant bacteria, such as clinically important Staphylococcus aureus. The essential multifunctional enzyme, biotin protein ligase (BPL), is one potential drug target f
NOVEL ANTIMICROBIAL COMPOUNDS
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, (2013/04/10)
A new class of biotin protein ligase (BPL) inhibitors that have antibacterial activity against multiple Staphylococcus aureus isolates, including clinically important methicillin-resistant S. aureus (MRSA) are disclosed that are non-toxic.
