1379667-19-2Relevant academic research and scientific papers
Manganese-Catalyzed C?H Amidation of Heteroarenes in Water
Kong, Xianqiang,Lin, Long,Xu, Bo
, p. 2801 - 2805 (2018/08/17)
We have developed an efficient manganese-catalyzed amidation of various heteroarenes via C?H bond activation using readily available sulfonyl azides. The key step is heteroarene directed electrophilic aromatic metalation using MnBr(CO)5 as catalyst. This method offers excellent chemical yields and regioselectivity with good functional group tolerance. This base metal catalyzed reaction proceeds efficiently using water as the only solvent and nitrogen is the only byproduct. (Figure presented.).
RuHCl(CO)(PPh3)3-Catalyzed Direct Amidation of Arene C-H Bond with Azides
Xiao, Xinsheng,Jia, Guokai,Liu, Fang,Ou, Guangchuan,Xie, Ying
, p. 13811 - 13820 (2018/11/23)
We first report the direct ortho C-H amidation of arenes with azides by using a novel and inexpensive RuHCl(CO)(PPh3)3 catalyst. The reaction proceeds efficiently in high yield over a broad range of substrates without requirement of any additional silver salt or additive.
Copper-catalyzed C(sp2)-H amidation with azides as amino sources
Peng, Jiangling,Xie, Zeqiang,Chen, Ming,Wang, Jian,Zhu, Qiang
supporting information, p. 4702 - 4705 (2015/04/27)
A copper-catalyzed C-H amidation process, with azides as amino sources under oxidant-free conditions, has been developed. When N-heterocycles were employed as directing groups, sulfonylazide and benzoylazide could be used as amidating reagents to provide corresponding N-arylamides. When amidines or imine were used, tandem C-N/N-N bond formation occurred to afford indazole derivatives in one pot.
Rhodium-catalyzed intermolecular amidation of arenes with sulfonyl azides via chelation-assisted C-H bond activation
Kim, Ji Young,Park, Sae Hume,Ryu, Jaeyune,Cho, Seung Hwan,Kim, Seok Hwan,Chang, Sukbok
, p. 9110 - 9113 (2012/07/14)
We report the direct amidation of arene C-H bonds using sulfonyl azides as the amino source to release N2 as the single byproduct. The reaction is catalyzed by a cationic rhodium complex under external oxidant-free conditions in the atmospheric environment. A broad range of chelate group-containing arenes are selectively amidated with excellent functional group tolerance, thus opening a new avenue to practical intermolecular C-N bond formation.
