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Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 512171-81-2 5-fluoro-2-phenylpyridine 
• 41404-58-4 2-bromo-5-fluoropyridine 
• 98-80-6 phenylboronic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 70-55-3 toluene-4-sulfonamide 

Relevant academic research and scientific papers

Rhodium(III)-catalyzed intermolecular N-chelator-directed aromatic C-H amidation with amides

Rh(III)-catalyzed intermolecular direct aromatic C-H bond amidation with amides has been accomplished under mild reaction conditions. This protocol is applicable to a broad range of N-chelator-containing arenes amidated with aromatic and aliphatic sulfonamides. A possible mechanism is proposed according to the experimental results.

Rhodium-catalyzed intermolecular amidation of arenes with sulfonyl azides via chelation-assisted C-H bond activation

We report the direct amidation of arene C-H bonds using sulfonyl azides as the amino source to release N2 as the single byproduct. The reaction is catalyzed by a cationic rhodium complex under external oxidant-free conditions in the atmospheric environment. A broad range of chelate group-containing arenes are selectively amidated with excellent functional group tolerance, thus opening a new avenue to practical intermolecular C-N bond formation.