137967-17-0Relevant academic research and scientific papers
One-Pot Synthesis of β,β-Disubstituted α,β-Unsaturated Carbonyl Compounds
Sugiura, Masaharu,Ashikari, Yasuhiko,Nakajima, Makoto
, p. 8830 - 8835 (2015/09/15)
TiCl4-promoted aldol reaction of ketones as aldol acceptors followed by elimination of the titanoxy group from the Ti-aldolates affords β,β-disubstituted α,β-unsaturated carbonyl compounds in a one-pot procedure. The use of additives, such as DMF, N,N,N′,N′-tetramethylethylenediamine, and pyridine, in the elimination step was found to be important.
Oxidative rearrangement of cyclic tertiary allylic alcohols with IBX in DMSO
Shibuya, Masatoshi,Ito, Shinichiro,Takahashi, Michiyasu,Iwabuchi, Yoshiharu
, p. 4303 - 4306 (2007/10/03)
(Chemical Equation Presented) A practical and environmentally friendly method for oxidative rearrangement of five- and six-membered cyclic tertiary allylic alcohols to β-disubstituted α,β-unsaturated ketones by the IBX/DMSO reagent system is described. Several conventional protecting groups (e.g., Ac, MOM, and TBDPS) are compatible under the reaction conditions prescribed.
Functional Group Hybrids. Reactivity of α'-Nucleofuge α,β-Unsaturated Ketones. 1. Reactions with Organocopper Reagents
Barbee, Thomas R.,Albizati, Kim F.
, p. 6764 - 6773 (2007/10/02)
A series of α-nucleofuge α',β'-unsaturated ketones encompassing a variety of structural types and nucleofuges was prepared.Treatment of these compounds with lithium dimethylcuprate or methylcopper leads primarily to either reductive cleavage of the α-nucl
