1379670-84-4

Basic information

• Product Name: 1-(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone
• Synonyms: 1-(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone
• CAS NO: 1379670-84-4
• Molecular Formula: C9H4BrCl3N2O
• Molecular Weight: 342.40386
• Mol File: 1379670-84-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.934±0.06 g/cm3(Predicted)
• PKA: 10.42±0.40(Predicted)
• CAS DataBase Reference: 1-(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone(1379670-84-4)
• EPA Substance Registry System: 1-(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone(1379670-84-4)

Safety Data

• Hazardous Substances Data: 1379670-84-4(Hazardous Substances Data)

Usage

General Description

1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone is a chemical compound with potential applications in the pharmaceutical industry. It is a derivative of pyrrolopyridine, which has been studied for its potential as an anticancer agent. The addition of the bromo group to the pyrrolopyridine core may enhance the compound's biological activity, making it a promising candidate for further drug development. The trichloroethanone moiety adds to the compound's potential by providing a reactive site for further chemical modifications. Overall, the chemical structure of 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,2,2-trichloroethanone makes it an interesting target for medicinal chemistry research and drug discovery.

Upstream product

• 76-02-8 trifluoroacetyl chloride 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1379669-93-8 3-[5-(3-fluorobenzyl)-1,3,4-oxadiazol-2-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1429309-37-4 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxamide 
• 1379670-87-7 5-bromo-3-[5-(3-fluorobenzyl)-1,3,4-oxadiazol-2-yl]-1H-pyrrolo[2,3-b]pyridine 
• 1379670-86-6 5-bromo-3-[5-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl]-1H-pyrrolo[2,3-b]pyridine 
• 1379669-87-0 3-[5-(3-fluorobenzyl)-1H-1,2,4-triazol-3-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 849068-61-7 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 

Relevant articles and documents

HETEROARYL COMPOUNDS AS NECROSIS INHIBITORS, COMPOSITION AND METHOD USING THE SAME

The present disclosure provides heteroaryl compounds of Formula (I), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from or related to necrosis. Formula (I) i

3-SUBSTITUTED PYRAZOLES AND USE AS DLK INHIBITORS

The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various embodiments thereof. (I) In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6 and R7 have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula (I) as DLK inhibitors and for treating neurodegeneration diseases and disorders.

NEW DERIVATIVES OF 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXAMIDE OR 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXYLIC ACID

The present invention relates to new compounds of formula I as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containin