1379675-91-8Relevant academic research and scientific papers
Cooperative catalytic reactions using distinct transition-metal catalysts: Ruthenium- and copper-catalyzed enantioselective propargylic alkylation
Ikeda, Masahiro,Miyake, Yoshihiro,Nishibayashi, Yoshiaki
supporting information; experimental part, p. 3321 - 3328 (2012/05/20)
The enantioselective propargylic alkylation of propargylic alcohols with β-ketoesters in the presence of a thiolate-bridged diruthenium complex and a copper complex as co-catalyst affords the corresponding propargylic alkylated products in excellent yields as a mixture of two diastereoisomers with high enantioselectivity (up to 95 % enantiomeric excess (ee)). The findings reported herein not only open up a new type of enantioselective propargylic substitution reaction, but also a new aspect of cooperative catalytic reactions using distinct transition metals to realize a useful transformation that cannot be achieved by a single catalyst. Copyright
