1379679-63-6Relevant academic research and scientific papers
Sodium acetate-catalyzed regiospecific and high stereoselective aminobromination of β,β-dicyanostyrene derivatives with NBS as nitrogen/bromine source
Li, Wenli,Chen, Zhanguo,Zhou, Jimei,Hu, Junli,Xia, Wei
, p. 830 - 836 (2012)
An easy and efficient method for the aminobromination of β,β-dicyanostyrene derivatives with NBS as the aminobrominating reagent in CH3CN catalyzed by NaOAc (10 mol%) is developed. This protocol provides convenient process to convert β,β-dicyanostyrene derivatives into the vicinal haloamines with full regiospecificity and high stereoselectivety in the ice-water bath in air. The reaction is high efficient in yielding the corresponding aminobrominated products in excellent yields (up to 95%) under these conditions. The outcome indicated that the reaction has an electrophilic addition feature. 12 Eexamples of β,β-dicyanostyrene derivatives have been investigated. An easy and efficient method for the aminobromination of β,β-dicyanostyrene derivatives with NBS as the aminobrominating reagent in CH3CN catalyzed by NaOAc (10 mol%) is developed. The reaction is high efficient in yielding the corresponding aminobrominated products in excellent yields (up to 95%). Copyright
