2826-26-8

Basic information

• Product Name: TYRPHOSTIN A1
• Synonyms: (4-METHOXYBENZYLIDENE)MALONITRILE;(4-METHOXYBENZYLIDENE)MALONONITRILE;((4-METHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE;2-[(4-METHOXYPHENYL)METHYLENE]MALONONITRILE;2-(4-METHOXYBENZYLIDENE)-MALONONITRILE;RARECHEM AL BX 0083;TYRPHOSTIN AG 9;TYRPHOSTIN A1
• CAS NO: 2826-26-8
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.19
• Mol File: 2826-26-8.mol
• Article Data: 142

Chemical Properties

• Melting Point: 113-116 °C(lit.)
• Boiling Point: 352.4°Cat760mmHg
• Flash Point: 148.8°C
• Appearance: /
• Density: 1.169g/cm³
• Vapor Pressure: 3.85E-05mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C
• Solubility: chloroform: soluble50mg/mL, clear, light yellow
• Sensitive: Light Sensitive
• CAS DataBase Reference: TYRPHOSTIN A1(CAS DataBase Reference)
• NIST Chemistry Reference: TYRPHOSTIN A1(2826-26-8)
• EPA Substance Registry System: TYRPHOSTIN A1(2826-26-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36/37
• RIDADR: UN 3439 6.1/PG III
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 2826-26-8(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline needles or crystals

Uses

Tyrphostin A1 is an inactive Tyrphostin used as a negative control for Tyrphostin A23.

Synthesis Reference(s)

Synthetic Communications, 21, p. 1163, 1991 DOI: 10.1080/00397919108021035Synthesis, p. 23, 1970

InChI:InChI=1/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3

Upstream product

• 1885-23-0 dibromomalononitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 36937-45-8 5-(4-Methoxyphenylmethylene)-2-morpholino-2-thiazolin-4-one 
• 109-77-3 malononitrile 
• 670-54-2 ethenetetracarbonitrile 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2393-23-9 4-methoxy-benzylamine 
• 75-15-0 carbon disulfide 
• 2700-23-4 4-Nitrobenzylidenemalononitrile 
• 245415-93-4 6-(4-Methoxyphenyl)-1,5-diazabicyclo[3.1.0]hexane 
• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 28162-32-5 2-(2-thienyl)-1-cyanoacrylonitrile 

Downstream Products

• 5553-92-4 2-(4-methoxybenzyl)malononitrile 
• 6731-49-3 bromo-(4-methoxy-benzyl)-malononitrile 
• 21448-00-0 Iod-(4-methoxybenzyl)-malodinitril 
• 6731-45-9 2-benzyl-2-(4-methoxyphenyl)malononitrile 
• 82912-28-5 C₁₇H₉N₆O^(1-)*C₄H₉N*H⁽¹⁺⁾ 
• 118464-20-3 7-Amino-5-(4-methoxy-phenyl)-5,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile 
• 119825-09-1 2-amino-4-(p-methoxyphenyl)-4H-pyrano<3,2-h>quinoline-3-carbonitrile 
• 123858-48-0 <(2,3-dihydro-2-oxo-1H-indol-3-yl)(4-methoxyphenyl)methyl>malononitrile 
• 145914-88-1 4-[(Z)-2-(4-Methoxy-phenyl)-vinyl]-7-phenyl-pyrazolo[5,1-c][1,2,4]triazine-3-carbonitrile 
• 126181-85-9 2-[(4-methoxyphenyl)(trimethylsilyl)methyl]malononitrile 
• 117362-36-4 4-amino-5-cyano-6-cyanomethyl-2-(1-cyano-2-p-anisidyl-ethylene)-pyrimidine 
• 77198-43-7 2-amino-4-(4-methoxyphenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile 
• 94638-87-6 4-(4-Methoxy-phenyl)-5,6-dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 94639-12-0 6-Amino-2-ethyl-4-(4-methoxy-phenyl)-2-methyl-4H-[1,3]dithiine-5-carbonitrile 

Relevant articles and documents

The Knoevenagel condensation catalysed by ionic liquids: a mass spectrometric insight into the reaction mechanism

The creation of carbon-carbon bonds is still a highly required topic in organic chemistry for the capacity to give a wide variety of new products of industrial value. Accordingly, the Knoevenagel condensation between activated methylene compounds and alde

Biguanide-functionalized hierarchical porous covalent organic frameworks for efficient catalysis of condensation reactions

Covalent organic frameworks (COFs) can be rationally designed with desired physicochemical properties for a far-ranging application in catalytic systems. Herein, a biguanide-functionalized covalent organic framework was designed and prepared via N-alkylat

Cascade reaction synthesis method of 2-(phenylmethylene)malononitrile or derivative thereof

The invention discloses a cascade reaction synthesis method of 2-(phenylmethylene)malononitrile or a derivative thereof. According to the invention, a dendritic acid-alkali catalyst based on cross-linked polystyrene is synthesized, and 2-(phenylmethylene) malononitrile or a derivative thereof is synthesized in batches by successfully applying a cascade reaction into fluid chemistry, so that the method of the invention has advantages of substantially reduced, yield increase and no separation process of a catalyst and a product compared with the traditional test tube reaction.