1379761-89-3Relevant academic research and scientific papers
OLIGONUCLEOTIDE LIGATION
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Page/Page column 38, (2018/08/03)
The present invention relates to a process for preparing certain oligonucleotides, in particular a process of ligating a first and a second oligonucleotide together. The present invention also relates to oligonucleotides obtained from this process and to
Molecular requirements of high-fidelity replication-competent DNA backbones for orthogonal chemical ligation
Shivalingam, Arun,Tyburn, Agnes E. S.,El-Sagheer, Afaf H.,Brown, Tom
, p. 1575 - 1583 (2017/02/10)
The molecular properties of the phosphodiester backbone that made it the evolutionary choice for the enzymatic replication of genetic information are not well understood. To address this, and to develop new chemical ligation strategies for assembly of bio
Triazole-linked oligonucleotides with mixed-base sequences: Synthesis and hybridization properties
Varizhuk, Anna,Chizhov, Alexandr,Smirnov, Igor,Kaluzhny, Dmitry,Florentiev, Vladimir
, p. 2173 - 2179 (2012/06/18)
A new class of backbone-modified oligonucleotide analogs has emerged since the discovery of the CuI-catalyzed [3+2] azide/alkyne cycloaddition reaction. These are oligonucleotide analogs with 1,4-disubstituted 1,2,3-triazoles as the internucleo
