1379767-72-2

Basic information

• Product Name: C₂₅H₂₈N₂O₆
• CAS NO: 1379767-72-2
• Molecular Weight: 452.507
• Mol File: 1379767-72-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₈N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₈N₂O₆(1379767-72-2)
• EPA Substance Registry System: C₂₅H₂₈N₂O₆(1379767-72-2)

Safety Data

• Hazardous Substances Data: 1379767-72-2(Hazardous Substances Data)

Upstream product

• 3265-25-6 N-methyl-3-tosylhydrazono-2-oxindole 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 67-56-1 methanol 
• 3265-14-3 3-diazo-1-methyl-1,3-dihydro-indol-2-one 
• 160527-44-6 (-)-(4S)-1-benzyl-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]-azetidine-2,3-dione 

Relevant articles and documents

Diastereoselective synthesis of β-Lactam-oxindole hybrids through a three-component reaction of azetidine-2,3-diones, α-diazo-oxindoles, and alcohols catalyzed by [Rh2(OAc)4]

β-Lactam-oxindole hybrids have been synthesized in good yields in a one-pot procedure through efficient and stereoselective capture of an oxonium ylide with azetidine-2,3-diones. The reaction allows high to moderate control of stereoselectivity, depending on the 3-diazo-oxindole precursor and the hydroxylic compound used. Two new quaternary stereogenic centers were formed; the stereochemistry at the C-3 quaternary center was controlled by a bulky substituent at C-4, whereas the stereoselectivity in the adjacent second quaternary stereogenic center was controlled by the α-diazo-oxindole. The stereochemistry of both quaternary centers has been unambiguously assigned by single-crystal X-ray diffraction. Densely functionalized β-lactam-oxindole hybrids have been prepared in a one-pot, multicomponent reaction between azetidine-2,3-diones, α-diazo-oxindoles, and alcohols. Two new stereogenic centers were formed; the stereochemistry at the new C-3 quaternary center was controlled by a bulky substituent at C-4, whereas the second new stereogenic center was controlled by the α-diazo-oxindole.