1379792-79-6Relevant articles and documents
Highly efficient synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b]pyrazine- 2,3-dicarbonitriles through a one-pot palladium-catalyzed coupling reaction/cyclization in water
Keivanloo, Ali,Bakherad, Mohammad,Nasr-Isfahani, Hossein,Esmaily, Somayeh
, p. 3126 - 3130 (2012/08/08)
A highly efficient one-pot synthesis of 5,6-disubstituted-5H-pyrrolo[2,3-b] pyrazine-2,3-dicarbonitriles is presented. The reaction of 5-(alkyl-arylamino)- 6-chloropyrazine-2,3-dicarbonitriles with phenylacetylene, catalyzed by Pd-Cu, in the presence of SDS as the surfactant in water, leads to the desired products in good-to-high yields.