1379799-58-2Relevant articles and documents
Sequential ring-closing metathesis-vinyl halide Heck cyclization reactions: Access to the tetracyclic ring system of ervitsine
Bennasar, M.-Llu?sa,Zulaica, Ester,Solé, Daniel,Alonso, Sandra
, p. 4641 - 4648 (2012)
A chemoselective indole-templated ring-closing metathesis is used to assemble the cyclohepta[b]indole substructure of the indole alkaloid ervitsine. A subsequent intramolecular Heck coupling of the resulting alkene functionality with an amino-tethered vinyl halide accomplishes the closure of the unique 2-azabicyclo[4.3.1]decane framework of the alkaloid with concomitant incorporation of the exocyclic E-ethylidene substituent.