1380059-30-2Relevant academic research and scientific papers
Feeding the Heck reaction with alcohol: One-pot synthesis of stilbenes from aryl alcohols and bromides
Colbon, Paul,Barnard, Jonathan H.,Purdie, Mark,Mulholland, Keith,Kozhevnikov, Ivan,Xiao, Jianliang
supporting information; scheme or table, p. 1395 - 1400 (2012/07/03)
Aryl alcohols are employed as feedstock for the Heck reaction. Keggin-type heteropolyacids catalyse the selective dehydration of the alcohols to styrenes, which, in one-pot, undergo palladium-catalysed Heck arylation with aryl bromides, affording broadly functionalised stilbenes. The choice of solvent is critical for the cascade dehydration-Heck reaction, with electron-rich aryl alcohols preferring a basic medium while electron-deficient ones demanding solvents of lower basicity. Copyright
