1380072-85-4Relevant academic research and scientific papers
Simple, multicomponent, ecofriendly, microwave-mediated route for the synthesis of antimicrobial 2-amino-6-aryl-4-(3 h)-pyrimidinones
Da Silva, Ivangela E. A.,Braga, Vanildo M. L.,Melo, Mychely S.,Correia, Maria Tereza Dos S.,Dos Anjos, Janaina V.
, p. 374 - 380 (2014)
In this work, we describe a multicomponent microwave-mediated synthesis of 10 2-amino-6-aryl-4-oxo-1,6-dihydro-pyrimidine-5-carbonitriles in good chemical yields (44-67%), four of them not related in earlier literature. All pyrimidinones synthesized herein had their antimicrobial activity evaluated against the following microorganisms: Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. Two of the synthesized substances displayed good antimicrobial activity against P. aeruginosa and S. aureus, two bacteria responsible for nosocomial infections. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
