1380109-93-2Relevant academic research and scientific papers
Pyridone-conjugated monobactam antibiotics with gram-negative activity
Brown, Matthew F.,Mitton-Fry, Mark J.,Arcari, Joel T.,Barham, Rose,Casavant, Jeffrey,Gerstenberger, Brian S.,Han, Seungil,Hardink, Joel R.,Harris, Thomas M.,Hoang, Thuy,Huband, Michael D.,Lall, Manjinder S.,Lemmon, M. Megan,Li, Chao,Lin, Jian,McCurdy, Sandra P.,McElroy, Eric,McPherson, Craig,Marr, Eric S.,Mueller, John P.,Mullins, Lisa,Nikitenko, Antonia A.,Noe, Mark C.,Penzien, Joseph,Plummer, Mark S.,Schuff, Brandon P.,Shanmugasundaram, Veerabahu,Starr, Jeremy T.,Sun, Jianmin,Tomaras, Andrew,Young, Jennifer A.,Zaniewski, Richard P.
supporting information, p. 5541 - 5552 (2013/07/26)
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Rat pharmacokinetic studies with compound 17 demonstrate low clearance and low plasma protein binding. In addition, evidence is provided for a number of analogues suggesting that the siderophore receptors PiuA and PirA play a role in drug uptake in P. aeruginosa strain PAO1.
MONOBACTAMS
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Page/Page column 60-61, (2012/06/16)
The present invention is directed to a new class of monobactam derivatives and their use for treating bacterial infections.
Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections
Mitton-Fry, Mark J.,Arcari, Joel T.,Brown, Matthew F.,Casavant, Jeffrey M.,Flanagan, Mark E.,Gerstenberger, Brian S.,Harris, Thomas M.,Hoang, Thuy,Lall, Manjinder S.,Li, Chao,Noe, Mark C.,Plummer, Mark S.,Risley, Hud,Schuff, Brandon P.,Starr, Jeremy T.,Sun, Jianmin,Young, Jennifer A.,Shanmugasundaram, Veerabahu,Finegan, Steven M.,George, David M.,Huband, Michael D.,Irvine, Rebecca,Megan Lemmon, M.,McCurdy, Sandra P.,Mueller, John P.,Mullins, Lisa,Penzien, Joseph,Gao, Hongying,Hardink, Joel R.,Lin, Jian,Niosi, Mark,Winton, Jennifer,Han, Seungil,Pattavina, David
, p. 5989 - 5994,6 (2020/08/31)
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.
