112334-42-6Relevant articles and documents
Preparation, gram-negative antibacterial activity, and hydrolytic stability of novel siderophore-conjugated monocarbam diols
Flanagan, Mark E.,Brickner, Steven J.,Lall, Manjinder,Casavant, Jeffrey,Deschenes, Laura,Finegan, Steven M.,George, David M.,Granskog, Karl,Hardink, Joel R.,Huband, Michael D.,Hoang, Thuy,Lamb, Lucinda,Marra, Andrea,Mitton-Fry, Mark,Mueller, John P.,Mullins, Lisa M.,Noe, Mark C.,O'Donnell, John P.,Pattavina, David,Penzien, Joseph B.,Schuff, Brandon P.,Sun, Jianmin,Whipple, David A.,Young, Jennifer,Gootz, Thomas D.
, p. 385 - 390 (2011/07/09)
A novel series of monocarbam compounds exhibiting promising antibacterial activity against multidrug resistant Gram-negative microorganisms is reported, along with the synthesis of one such molecule MC-1 (1). Also reported are structure-activity relationships associated with the in vitro and in vivo efficacy of 1 and related analogues in addition to the hydrolytic stability of such compounds and possible implications thereof.
3-Acylamino-1-[[[(substituted sulfonyl)amino]carbonyl]amino]2-azetidinones
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, (2008/06/13)
Compounds having the formula and pharmaceutically acceptable salts thereof, exhibit antibacterial activity.
1-(substituted phosphorous)-azetidinone antibacterials
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, (2008/06/13)
Antibacterial activity is exhibited by 2-azetidinones having an acylamino substituent in the 3-position and having an activating group in the 1-position of the formula STR1