1380208-84-3Relevant academic research and scientific papers
Reactions Catalysed by a Binuclear Copper Complex: Aerobic Cross Dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines
Liu, Yuxia,Wang, Chao,Xue, Dong,Xiao, Miao,Li, Chaoqun,Xiao, Jianliang
, p. 3051 - 3061 (2017)
Binuclear copper complex [{Cu(Sal)2(NCMe)}2] (Sal=salicylate) was found to be an active catalyst for the aerobic oxidation of N-aryl tetrahydroisoquinolines to the corresponding iminium ions, which could be trapped by a wide range of nucleophiles to form coupled products. The reactions took place under 1 bar of O2 at room temperature with 1 mol % of the copper catalyst being sufficient in most cases, and are considerably accelerated by catalytic chloride anions. Mechanistic studies show that the CuII dimer oxidizes the amine to the iminium ion, and this two-electron process requires O2, whereby the resulting CuI is concomitantly reoxidised back to CuII. Various lines of evidence suggest that the oxidative coupling reaction is turnover-limited by the step of iminium formation, and it is this step that is promoted by the chloride anion. Since it is more efficient than and mechanistically distinct from the well-studied simple copper salts such as CuBr and CuCl2, the binuclear copper catalyst provides a new tool for oxidative coupling reactions.
A versatile C-H functionalization of tetrahydroisoquinolines catalyzed by iodine at aerobic conditions
Dhineshkumar, Jayaraman,Lamani, Manjunath,Alagiri, Kaliyamoorthy,Prabhu, Kandikere Ramaiah
supporting information, p. 1092 - 1095 (2013/03/29)
A versatile aerobic catalytic system (I2 and O2/TBHP) for C-H functionalization is reported. This CDC (cross-dehydrogentive coupling) reaction is compatible with a large number of nucleophiles and is performed under ambient reaction
CDC reactions of N-aryl tetrahydroisoquinolines using catalytic amounts of DDQ: C-H activation under aerobic conditions
Alagiri, Kaliyamoorthy,Devadig, Pradeep,Prabhu, Kandikere R.
supporting information; experimental part, p. 5160 - 5164 (2012/05/20)
An oxidative cross-dehydrogenative coupling (CDC) reaction for the formation of C-C and C-P bonds is disclosed using a catalytic amount of DDQ (10 mol %) under aerobic conditions (see scheme). This unprecedented environmentally benign strategy of using AI
