1380229-04-8

Basic information

• Product Name: N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2,5-dimethylfuran-3-sulfonamide
• Synonyms: N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2,5-dimethylfuran-3-sulfonamide
• CAS NO: 1380229-04-8
• Molecular Weight: 581.603
• Mol File: 1380229-04-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2,5-dimethylfuran-3-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2,5-dimethylfuran-3-sulfonamide(1380229-04-8)
• EPA Substance Registry System: N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2,5-dimethylfuran-3-sulfonamide(1380229-04-8)

Safety Data

• Hazardous Substances Data: 1380229-04-8(Hazardous Substances Data)

Upstream product

• 1093101-52-0 6-(2-fluoropyridin-3-yl)-9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purine 
• 7306-68-5 6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine 
• 535170-20-8 tert-butyl (3-amino-2,6-difluorophenyl)carbamate 
• 535170-17-3 tert-butyl (2,6-difluoro-3-nitrophenyl)carbamate 
• 83141-10-0 2,6-difluoro-3-nitrobenzoic acid 
• 1380228-71-6 benzyl 2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl carbamate 
• 166964-26-7 2,5-dimethyl-furan-3-ylsulphonyl chloride 
• 1380228-73-8 2,6-difluoro-N₁-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)benzene-1,3-diamine 
• 1380228-68-1 benzyl tert-butyl (2,4-difluoro-1,3-phenylene)dicarbamate 
• 110-87-2 3,4-dihydro-2H-pyran 
• 87-42-3 6-chloropurine 
• 260552-98-5 2,6-difluoro-3-nitrobenzoic acid chloride 
• 385-00-2 2,6-difluorobenzoic acid 

Downstream Products

• 1380228-43-2 N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-2,5-dimethylfuran-3-sulfonamide 

Relevant articles and documents

Discovery of a highly specific and potent pan-RAF inhibitor

We describe the structure-based design and synthesis of N-(2,6-difluorophenyl)-3-(9H-purin-6-yl)pyridine-2-amine derivatives as a selective pan-RAF kinase inhibitor. The synthesized compounds showed highly potent and specific inhibition of the BRAFV600E mutant cell line. Among them, N-(3-((3-(9H-purin-6-yl) pyridine-2-yl)amino)-2,4-difluorophenyl)furan-3-sulfonamide (4b) exhibited the most potent inhibitory activities against protein kinase enzymes BRAFV600E, BRAFWT, and CRAF (IC50 of 2, 2, and 1 nM, respectively) and a mutant cell line bearing a BRAFV600E mutation, A375P (GI50 of 7 nM).