1380234-95-6

Basic information

• Product Name: N-(4-(trifluoromethyl)benzyl)quinazolin-2-amine
• Synonyms: N-(4-(trifluoromethyl)benzyl)quinazolin-2-amine
• CAS NO: 1380234-95-6
• Molecular Weight: 303.287
• Mol File: 1380234-95-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-(trifluoromethyl)benzyl)quinazolin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(trifluoromethyl)benzyl)quinazolin-2-amine(1380234-95-6)
• EPA Substance Registry System: N-(4-(trifluoromethyl)benzyl)quinazolin-2-amine(1380234-95-6)

Safety Data

• Hazardous Substances Data: 1380234-95-6(Hazardous Substances Data)

Upstream product

• 6141-13-5 2-chloroquinazoline 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 1687-51-0 quinazolin-2-ylamine 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 

Relevant articles and documents

Nucleophilic aromatic substitution of heterocycles using a high-temperature and high-pressure flow reactor

We report herein a high-temperature and high-pressure continuous-flow protocol to carry out nucleophilic aromatic substitution (SNAr) of heterocycles with nitrogen nucleophiles. Utilizing the Phoenix Flow Reactor in parallel with Design-of-Experiment software enabled rapid optimization of the SNAr protocol. This protocol facilitated efficient synthesis of a broad range of 2-aminoquinazolines, and was extended to 2-aminoquinoxalines and 2-aminobenzimidazoles.