6141-13-5

Basic information

• Product Name: 2-Chloroquinazoline
• Synonyms: 2-chloroquinazoline;2-Chloroquinazoline(WX636001)
• CAS NO: 6141-13-5
• Molecular Formula: C₈H₅ClN₂
• Molecular Weight: 164.59
• Product Categories: CHIRAL CHEMICALS
• Mol File: 6141-13-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 108 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 250 °C at 760 mmHg
• Flash Point: 129.2 °C
• Appearance: /
• Density: 1.349 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.22±0.30(Predicted)
• CAS DataBase Reference: 2-Chloroquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloroquinazoline(6141-13-5)
• EPA Substance Registry System: 2-Chloroquinazoline(6141-13-5)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 6141-13-5(Hazardous Substances Data)

Usage

General Description

2-Chloroquinazoline is a chemical compound with the molecular formula C8H6ClN2. It is a heterocyclic compound with a quinazoline ring that contains a chlorine atom. 2-Chloroquinazoline has diverse applications in the field of organic synthesis and pharmaceutical development. It is used as an intermediate for the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals. Additionally, 2-Chloroquinazoline exhibits antiproliferative and cytotoxic effects and has potential applications in cancer treatment research. It is also used as a building block in the synthesis of other biologically active compounds. Overall, 2-Chloroquinazoline is a versatile chemical compound with a wide range of applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C8H5ClN2/c9-8-10-5-6-3-1-2-4-7(6)11-8/h1-5H

Upstream product

• 193001-44-4 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride 
• 108-95-2 phenol 
• 204520-39-8 4-(α-methyl-α-hydroxy-p-bromobenzyl)-2-chloroquinazoline 
• 43120-25-8 1-benzyl-1H-indazole 
• 67-66-3 chloroform 

Downstream Products

• 952443-60-6 2-chloro-4-cyclohexylquinazoline 
• 851012-56-1 2-chloro-4-(2-fluorophenyl)quinazoline 
• 29874-83-7 2-chloro-4-phenylquinazoline 

Relevant articles and documents

SUBSTITUTED QUINAZOLINES

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Pyrolysis of 1-substituted pyrazoles and chloroform at 550°C: Formation of α-carboline from 1-benzylpyrazoles

Pyrolysis of 13CH3 labelled 1-methylpyrazole 8 with chloroform at 550°C in a continuous flow reactor yields unlabelled 2-chloropyrimidine 9 and 2-cyanopyrrole 10 labelled at the cyano group. However, pyrolysis of 1-benzylpyrazole 14 with chloroform under similar conditions gives 9,2-phenylpyrimidine 13 and, as the major product, α-carboline 15. Pyrolysis of several substituted 1-(arylmethyl)pyrazoles and the use of 13C and 15N labelled compounds provides direct evidence by which the positions of 7 atoms of 1-benzylpyrazole can be located in the α-carboline. These data support the mechanisms suggested for the formation of 9, 10, and 15.