138026-77-4Relevant academic research and scientific papers
Designing a catalytic synthesis of 4-methylcoumarin from ortho-iodophenyl 3-butenoate: Ring closure and isomerization control
Catellani, Marta,Chiusoli, Gian Paolo,Marzolini, Giovanna,Rossi, Emanuela
, p. 65 - 69 (1996)
The palladium-catalyzed ring closure of ortho-iodophenyl 3-butenoate to 4-methylcoumarin is in competition with the isomerization to the 2-butenoic ester; the latter reaction has been controlled by the appropriate use of ligands, solvents and neutralizing agents to the point that quantitative yields of the cyclic compound have been attained.
