1380313-68-7Relevant articles and documents
Method for directly preparing alkyl borate compound from alkyl halide
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Paragraph 0226-0228, (2021/04/14)
The invention relates to a method for directly preparing an alkyl borate compound from an alkyl halide, which comprises the following steps: in a protective atmosphere, mixing a titanium metal catalyst, an alkali compound, a borate compound and an alkyl halide or sulfonate compound, reacting at 35-100 DEG C for 8-24 hours, so that the alkyl halide or sulfonate compound is directly converted into the alkyl boronic acid pinacol ester compound. The method is simple to operate, low in cost, good in functional group tolerance and wide in substrate application range.
Efficient synthesis of alkylboronic esters: Via magnetically recoverable copper nanoparticle-catalyzed borylation of alkyl chlorides and bromides
Shegavi, Mahadev L.,Agarwal, Abhishek,Bose, Shubhankar Kumar
supporting information, p. 2799 - 2803 (2020/06/17)
We report a magnetically separable Cu nanocatalyst (Fe-DOPA-Cu) for the borylation of alkyl halides with alkoxy diboron reagents, providing alkylboronic esters in high yields, with broad functional group tolerance under mild reaction conditions. The procedure is also applicable to the borylation of benzyl chlorides and bromides. Radical clock experiments support a radical-mediated process. Easy recycling of the catalyst resulted in no significant loss of activity up to ten runs.
Highly efficient synthesis of alkylboronate esters via Cu(II)-Catalyzed borylation of unactivated alkyl bromides and chlorides in air
Bose, Shubhankar Kumar,Brand, Simon,Omoregie, Helen Oluwatola,Haehnel, Martin,Maier, Jonathan,Bringmann, Gerhard,Marder, Todd B.
, p. 8332 - 8335 (2018/05/22)
A copper(II)-catalyzed borylation of alkyl halides with bis(pinacolato)diboron (B2pin2) has been developed, which can be carried out in air, providing a wide range of primary, secondary, and some tertiary alkylboronates in high yields. A variety of functional groups are tolerated and the protocol is also applicable to unactivated alkyl chlorides (including 1,1- and 1,2-dichlor-ides). Preliminary mechanistic investigations show that this borylation reaction involves one-electron processes.