1380341-57-0Relevant articles and documents
Ni-catalyzed reductive coupling of α-halocarbonyl derivatives with vinyl bromides
Qiu, Canbin,Yao, Ken,Zhang, Xinghua,Gong, Hegui
, p. 11332 - 11335 (2016)
This work describes the vinylation of α-halo carbonyl compounds with vinyl bromides under Ni-catalyzed reductive coupling conditions. While aryl-conjugated vinyl bromides entail pyridine as the sole labile ligand, the alkyl-substituted vinyl bromides require both bipyridine and pyridine as the co-ligands.
Nickel-catalyzed heck-type alkenylation of secondary and tertiary α-carbonyl alkyl bromides
Liu, Chao,Tang, Shan,Liu, Dong,Yuan, Jiwen,Zheng, Liwei,Meng, Lingkui,Lei, Aiwen
supporting information; experimental part, p. 3638 - 3641 (2012/05/20)
Ni made it! A novel Heck-type reaction of secondary and tertiary α-carbonyl alkyl bromides, most likely involving a radical process, was achieved through the use of a nickel catalyst. Various substituted styrenes and 1,1-diaryl alkenes were utilized as substrates to easily construct α-alkenyl carbonyl compounds with tertiary or quaternary carbon centers. A catalytic cycle involving NiI/NiII is proposed based on our experimental results. EWG=electron-withdrawing group.
