1380424-55-4Relevant academic research and scientific papers
Palladium-catalyzed regioselective and stereoselective oxidative heck arylation of allylamines with arylboronic acids
Zhang, Lingjuan,Dong, Chaonan,Ding, Chenjun,Chen, Jing,Tang, Weijun,Li, Huanrong,Xu, Lijin,Xiao, Jianliang
supporting information, p. 1570 - 1578 (2013/06/27)
A general and convenient palladium-catalyzed oxidative Heck arylation of both N-protected and N,N-diprotected allylic amines with arylboronic acids under mild conditions has been developed. The catalyst system, consisting of Pd(OAc)2 (palladium acetate), AgOAc (silver acetate) and KHF 2 (potassium hydrogen fluoride), could efficiently catalyze the coupling reaction in acetone without the aid of any ligand, leading exclusively to the γ-arylated allylic amine products in good to excellent yields. This method is highlighted with excellent regio- and stereocontrol and remarkable functional group tolerance. The carbamate moiety in allylic amine substrates is of crucial importance to the catalytic performance, and the chelation between the carbonyl O (oxygen) and Pd (palladium) atoms is believed to be responsible for the high regioselectivity and stereoselectivity observed. Copyright
Palladium-catalyzed highly regioselective and stereoselective arylation of electron-rich allylamines with aryl bromides
Jiang, Zhen,Zhang, Lingjuan,Dong, Chaonan,Ma, Baode,Tang, Weijun,Xu, Lijin,Fan, Qinghua,Xiao, Jianliang
experimental part, p. 4919 - 4926 (2012/07/28)
A palladium-catalyzed, highly efficient Heck arylation of electron-rich N,N-diprotected allylamine derivatives with a wide range of aryl bromides under ligand-free conditions has been developed. In the presence of Pd(OAc) 2 and an appropriate a
